ID   C77A1_SOLME             Reviewed;         499 AA.
AC   P37123;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Cytochrome P450 77A1;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPLXXVIIA1;
DE   AltName: Full=Cytochrome P-450EG6;
DE   Flags: Fragment;
GN   Name=CYP77A1; Synonyms=CYPEG6;
OS   Solanum melongena (Eggplant) (Aubergine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Sinsadoharanasu; TISSUE=Hypocotyl;
RX   PubMed=8307197; DOI=10.1016/0014-5793(94)80286-6;
RA   Toguri T., Tokugawa K.;
RT   "Cloning of eggplant hypocotyl cDNAs encoding cytochromes P450 belonging to
RT   a novel family (CYP77).";
RL   FEBS Lett. 338:290-294(1994).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; X71656; CAA50647.1; -; mRNA.
DR   PIR; S41599; S41599.
DR   AlphaFoldDB; P37123; -.
DR   SMR; P37123; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
FT   CHAIN           <1..499
FT                   /note="Cytochrome P450 77A1"
FT                   /id="PRO_0000052145"
FT   BINDING         443
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   499 AA;  57077 MW;  569DE4211E079D0B CRC64;
     IFTAFSLLFS LFIFLLTRKP KSKTPNLPPG PPGWPIVGNL FQVAGSGKQF FEYIRDLKPK
     YGSIFTLKMG SRTMIIVASA ELAHEALIQK GQIFASRPRE NPTRTIFSCN KFSVNAAVYG
     PVWRSLRRNM VQNMLSPSRL KEFREFREIA MDKLIERIRV DAKENNDVVW ALKNARFAVF
     YILVAMCFGV EMDNEEMIER VDQMMKDVLI VLDPRIDDFL PILRLFVGYK QRKRVNEVRK
     RQIETLVPLI EKRRSVVQNP GSDKTAASFS YLDTLFDVKV EGRKSGPTNA ELVTLCSEFL
     NGGTDTTATA LEWGIGRLME NPTIQNQLYQ EIKTIVGDKK VDENDIEKMP YLNAVVKELL
     RKHPPTYFTL THSVTEPVKL AGYDIPMDTN VEFFVHGISH DPNVWSDPEK FDPDRFLSGR
     EDADITGVKE VKMMPFGVGR RICPGLGMAT VHVNLMLARM VQEFEWFAYP GNNKVDFSEK
     LEFTVVMKNP LRAKVKLRI