ID   C77A2_SOLME             Reviewed;         511 AA.
AC   P37124;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Cytochrome P450 77A2;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPLXXVIIA2;
DE   AltName: Full=Cytochrome P-450EG5;
GN   Name=CYP77A2; Synonyms=CYPEG5;
OS   Solanum melongena (Eggplant) (Aubergine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Sinsadoharanasu; TISSUE=Hypocotyl;
RX   PubMed=8307197; DOI=10.1016/0014-5793(94)80286-6;
RA   Toguri T., Tokugawa K.;
RT   "Cloning of eggplant hypocotyl cDNAs encoding cytochromes P450 belonging to
RT   a novel family (CYP77).";
RL   FEBS Lett. 338:290-294(1994).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; X71655; CAA50646.1; -; mRNA.
DR   PIR; S41598; S41598.
DR   AlphaFoldDB; P37124; -.
DR   SMR; P37124; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
FT   CHAIN           1..511
FT                   /note="Cytochrome P450 77A2"
FT                   /id="PRO_0000052146"
FT   BINDING         456
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   511 AA;  58115 MW;  4B2A185D4DAFE023 CRC64;
     MDFFSTSSLS SYYHLIFTIL AFVISSIIYF LSKKAESKKL KLPPGPPGWP VVGNLLQVAR
     SGKPFFQIMR ELRQKYGPIF TLRMGTRTMI ILSNADLVHE ALILKGQVFA TRPRENPTRT
     VFSCDKFTVN AAVYGPVWRS LRKNMVQNGL SSIRLKEFRA VRKSAMDKMI EKIRAEADAN
     EGVVWVLKNA RFAVFCILLA MCFGVEMDEK TIEKIDQMMK SVLIALDPRL DDYLPILSPF
     FSKQRKHAMD VRKQQIKTIV PFIEQRKKIL ESPEIDKTAA SFSYLDTLFD LKIEGRNSTP
     TYPELVTLCS EFLNGGTDTT ATAIEWAIGR LIENPNIQSQ LYEEIKKTVG ENKIDEKDIE
     KMPYLNAVVK ELLRKHPPTY MSLTHAVTEP AKLGGYDIPT GVNVEIFLPG ISDDPNLWSE
     PEKFDPDRFY LGKEDADITG VSGVKMIPFG MGRRICPGLN MATVHVSLML ARLVQEFEWA
     DPENTRVDFT EKLEFTVVMK NTLRAKIKPR M