ID   C78A3_SOYBN             Reviewed;         523 AA.
AC   O48927;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cytochrome P450 78A3;
DE            EC=1.14.-.-;
GN   Name=CYP78A3;
OS   Glycine max (Soybean) (Glycine hispida).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC   Glycine subgen. Soja.
OX   NCBI_TaxID=3847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Siminszky B., Dewey R.E., Corbin F.T.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AF022463; AAB94592.1; -; mRNA.
DR   PIR; T05946; T05946.
DR   RefSeq; NP_001304524.1; NM_001317595.1.
DR   AlphaFoldDB; O48927; -.
DR   SMR; O48927; -.
DR   STRING; 3847.GLYMA19G44790.1; -.
DR   PRIDE; O48927; -.
DR   GeneID; 100799906; -.
DR   KEGG; gmx:100799906; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   InParanoid; O48927; -.
DR   Proteomes; UP000008827; Unplaced.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..523
FT                   /note="Cytochrome P450 78A3"
FT                   /id="PRO_0000052150"
FT   BINDING         467
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   523 AA;  58565 MW;  39479B3DE2E810D1 CRC64;
     MTSHIDDNLW IIALTSKCTQ ENLAWVLLIM GSLWLTMTFY YWSHPGGPAW GKYYTYSPPL
     SIIPGPKGFP LIGSMGLMTS LAHHRIAAAA ATCRAKRLMA FSLGDTRVIV TCHPDVAKEI
     LNSSVFADRP VKESAYSLMF NRAIGFASYG VYWRSLRRIA SNHLFCPRQI KASELQRSQI
     AAQMVHILNN KRHRSLRVRQ VLKKASLSNM MCSVFGQEYK LHDPNSGMED LGILVDQGYD
     LLGLFNWADH LPFLAHFDAQ NIRFRCSNLV PMVNRFVGTI IAEHRASKTE TNRDFVDVLL
     SLPEPDQLSD SDMIAVLWEM IFRGTDTVAV LIEWILARMA LHPHVQSKVQ EELDAVVGKA
     RAVAEDDVAV MTYLPAVVKE VLRLHPPGPL LSWARLSIND TTIDGYHVPA GTTAMVNTWA
     ICRDPHVWKD PLEFMPERFV TAGGDAEFSI LGSDPRLAPF GSGRRACPGK TLGWATVNFW
     VASLLHEFEW VPSDEKGVDL TEVLKLSSEM ANPLTVKVRP RRG