UB2V1_CHICK
ID UB2V1_CHICK Reviewed; 145 AA.
AC Q90879;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Ubiquitin-conjugating enzyme E2 variant 1;
DE Short=UEV-1;
DE AltName: Full=CROC-1B;
GN Name=UBE2V1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cerebellum;
RA Hannan A.J., Henke R.C., Jeffrey P.L.;
RT "Differentially expressed genes in the developing nervous system.";
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N
CC heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin
CC chains that are linked through 'Lys-63'. This type of poly-
CC ubiquitination activates IKK and does not seem to involve protein
CC degradation by the proteasome. Plays a role in the activation of NF-
CC kappa-B. Mediates transcriptional activation of target genes. Plays a
CC role in the control of progress through the cell cycle and
CC differentiation. Plays a role in the error-free DNA repair pathway and
CC contributes to the survival of cells after DNA damage (By similarity).
CC Together with RNF135 and UBE2N, may catalyze the viral RNA-dependent
CC 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the
CC downstream signaling pathway that leads to interferon beta production
CC (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q13404}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Excluded from the
CC nucleolus. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB04629.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L77699; AAB04629.1; ALT_INIT; mRNA.
DR RefSeq; NP_001192026.1; NM_001205097.1.
DR AlphaFoldDB; Q90879; -.
DR BMRB; Q90879; -.
DR SMR; Q90879; -.
DR STRING; 9031.ENSGALP00000012992; -.
DR PaxDb; Q90879; -.
DR GeneID; 100538349; -.
DR KEGG; gga:100538349; -.
DR CTD; 7335; -.
DR VEuPathDB; HostDB:geneid_100538349; -.
DR eggNOG; KOG0896; Eukaryota.
DR HOGENOM; CLU_063065_3_0_1; -.
DR InParanoid; Q90879; -.
DR OrthoDB; 1507995at2759; -.
DR PhylomeDB; Q90879; -.
DR Reactome; R-GGA-433871; TRAF6 mediated induction of proinflammatory cytokines.
DR PRO; PR:Q90879; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006301; P:postreplication repair; IBA:GO_Central.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR Pfam; PF00179; UQ_con; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..145
FT /note="Ubiquitin-conjugating enzyme E2 variant 1"
FT /id="PRO_0000292584"
FT DOMAIN 10..145
FT /note="UBC core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
SQ SEQUENCE 145 AA; 16335 MW; A95530C5270FEB19 CRC64;
MAATTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTIYEN
RIYSLKIECG PKYPEAPPFV RFVTKINMNG VNSSNGVVDP RAISVLAKWQ NSFSIKVVLQ
ELRRLMMSKE NMKLPQPPEG QCYSN
