ID   UB2V2_BOVIN             Reviewed;         145 AA.
AC   Q3SZ43;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Ubiquitin-conjugating enzyme E2 variant 2;
GN   Name=UBE2V2; Synonyms=UEV2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N
CC       heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin
CC       chains that are linked through 'Lys-63'. This type of poly-
CC       ubiquitination does not lead to protein degradation by the proteasome.
CC       Mediates transcriptional activation of target genes. Plays a role in
CC       the control of progress through the cell cycle and differentiation.
CC       Plays a role in the error-free DNA repair pathway and contributes to
CC       the survival of cells after DNA damage (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with UBE2N. Binds CHFR (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00388}.
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DR   EMBL; BC103159; AAI03160.1; -; mRNA.
DR   RefSeq; NP_001029214.1; NM_001034042.2.
DR   AlphaFoldDB; Q3SZ43; -.
DR   SMR; Q3SZ43; -.
DR   STRING; 9913.ENSBTAP00000031532; -.
DR   PaxDb; Q3SZ43; -.
DR   PeptideAtlas; Q3SZ43; -.
DR   PRIDE; Q3SZ43; -.
DR   GeneID; 286803; -.
DR   KEGG; bta:286803; -.
DR   CTD; 7336; -.
DR   eggNOG; KOG0896; Eukaryota.
DR   HOGENOM; CLU_063065_3_0_1; -.
DR   InParanoid; Q3SZ43; -.
DR   OrthoDB; 1507995at2759; -.
DR   TreeFam; TF316971; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006301; P:postreplication repair; IBA:GO_Central.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Reference proteome; Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q15819"
FT   CHAIN           2..145
FT                   /note="Ubiquitin-conjugating enzyme E2 variant 2"
FT                   /id="PRO_0000247439"
FT   DOMAIN          10..145
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15819"
SQ   SEQUENCE   145 AA;  16363 MW;  98D632A1AEC0AADE CRC64;
     MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN
     RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ
     ELRRLMMSKE NMKLPQPPEG QTYNN