UB2V2_CHICK
ID UB2V2_CHICK Reviewed; 144 AA.
AC Q5F3Z3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Ubiquitin-conjugating enzyme E2 variant 2;
GN Name=UBE2V2; ORFNames=RCJMB04_4b12;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N
CC heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin
CC chains that are linked through 'Lys-63'. This type of poly-
CC ubiquitination does not lead to protein degradation by the proteasome.
CC Mediates transcriptional activation of target genes. Plays a role in
CC the control of progress through the cell cycle and differentiation.
CC Plays a role in the error-free DNA repair pathway and contributes to
CC the survival of cells after DNA damage (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with UBE2N. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC {ECO:0000255|PROSITE-ProRule:PRU00388}.
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DR EMBL; AJ851507; CAH65141.1; -; mRNA.
DR RefSeq; NP_001026189.1; NM_001031018.1.
DR AlphaFoldDB; Q5F3Z3; -.
DR SMR; Q5F3Z3; -.
DR STRING; 9031.ENSGALP00000041832; -.
DR PaxDb; Q5F3Z3; -.
DR GeneID; 421109; -.
DR KEGG; gga:421109; -.
DR CTD; 7336; -.
DR VEuPathDB; HostDB:geneid_421109; -.
DR eggNOG; KOG0896; Eukaryota.
DR HOGENOM; CLU_063065_3_0_1; -.
DR InParanoid; Q5F3Z3; -.
DR OrthoDB; 1507995at2759; -.
DR PhylomeDB; Q5F3Z3; -.
DR TreeFam; TF316971; -.
DR PRO; PR:Q5F3Z3; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006301; P:postreplication repair; IBA:GO_Central.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR Pfam; PF00179; UQ_con; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..144
FT /note="Ubiquitin-conjugating enzyme E2 variant 2"
FT /id="PRO_0000292586"
FT DOMAIN 9..144
FT /note="UBC core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
SQ SEQUENCE 144 AA; 16305 MW; 515EC84081944B0F CRC64;
MAGSTVKVPR NFRLLEELEE GQKGVGDGTV SWGLEDDEDM TLTRWTGMII GPPRTNYENR
IYSLKVECGP KYPEAPPTVR FVTKINMNGI NNSNGMVDAR SIPVLAKWQN SYSIKVVLQE
LRRLMMSKEN MKLPQPPEGQ TYNN