UB2V2_DANRE
ID UB2V2_DANRE Reviewed; 145 AA.
AC Q6PEH5;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Ubiquitin-conjugating enzyme E2 variant 2;
GN Name=ube2v2; ORFNames=zgc:63717;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has no ubiquitin ligase activity on its own. The ube2v2/ube2n
CC heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin
CC chains that are linked through 'Lys-63'. This type of poly-
CC ubiquitination does not lead to protein degradation by the proteasome.
CC Mediates transcriptional activation of target genes. Plays a role in
CC the control of progress through the cell cycle and differentiation.
CC Plays a role in the error-free DNA repair pathway and contributes to
CC the survival of cells after DNA damage (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with ube2n. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC058061; AAH58061.1; -; mRNA.
DR RefSeq; NP_998680.1; NM_213515.1.
DR AlphaFoldDB; Q6PEH5; -.
DR SMR; Q6PEH5; -.
DR BioGRID; 91380; 3.
DR STRING; 7955.ENSDARP00000004795; -.
DR PaxDb; Q6PEH5; -.
DR PRIDE; Q6PEH5; -.
DR Ensembl; ENSDART00000026578; ENSDARP00000004795; ENSDARG00000028198.
DR GeneID; 406836; -.
DR KEGG; dre:406836; -.
DR CTD; 7336; -.
DR ZFIN; ZDB-GENE-040426-2919; ube2v2.
DR eggNOG; KOG0896; Eukaryota.
DR GeneTree; ENSGT00740000115534; -.
DR HOGENOM; CLU_063065_3_0_1; -.
DR InParanoid; Q6PEH5; -.
DR OMA; WQSSYSI; -.
DR OrthoDB; 1507995at2759; -.
DR PhylomeDB; Q6PEH5; -.
DR TreeFam; TF316971; -.
DR Reactome; R-DRE-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR Reactome; R-DRE-5693571; Nonhomologous End-Joining (NHEJ).
DR Reactome; R-DRE-5693607; Processing of DNA double-strand break ends.
DR Reactome; R-DRE-5696395; Formation of Incision Complex in GG-NER.
DR Reactome; R-DRE-69473; G2/M DNA damage checkpoint.
DR Reactome; R-DRE-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q6PEH5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 24.
DR Bgee; ENSDARG00000028198; Expressed in somite and 29 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006301; P:postreplication repair; IBA:GO_Central.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IDA:ZFIN.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR Pfam; PF00179; UQ_con; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..145
FT /note="Ubiquitin-conjugating enzyme E2 variant 2"
FT /id="PRO_0000292587"
FT DOMAIN 10..145
FT /note="UBC core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
SQ SEQUENCE 145 AA; 16324 MW; E7C003AD2FC38138 CRC64;
MAASSGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPARTNYEN
RIYSLKVECG PKYPEVPPTV RFVTKISMNG INNSNGMVDA RSIPILAKWQ NSYSIKVVLQ
ELRRLMMSKE NMKLPQPPEG QTYSN
