ID   C78A4_PINRA             Reviewed;         553 AA.
AC   O65012;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Cytochrome P450 78A4;
DE            EC=1.14.-.-;
GN   Name=CYP78A4; Synonyms=PRE74;
OS   Pinus radiata (Monterey pine) (Pinus insignis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Pinopsida; Pinidae; Conifers I; Pinales; Pinaceae; Pinus;
OC   Pinus subgen. Pinus.
OX   NCBI_TaxID=3347;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bishop-Hurley S.L., Walter C., Gardner R.C.;
RT   "Isolation and expression of abundant mRNAs during somatic embryogenesis of
RT   Pinus radiata.";
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AF049067; AAC05148.1; -; mRNA.
DR   PIR; T08114; T08114.
DR   AlphaFoldDB; O65012; -.
DR   SMR; O65012; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
FT   CHAIN           1..553
FT                   /note="Cytochrome P450 78A4"
FT                   /id="PRO_0000052149"
FT   BINDING         491
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   553 AA;  62027 MW;  FC4ED38BAD264018 CRC64;
     MENRRSSGGS GWWVCVLPLF TKDGPAYFLH SSSDDVSAWR QWPLYIALLI VAVCAVLVSW
     LSPGGCAWAG RHKRGRVAIP GPKGWPIIGS LMDMSVGLPH RKLESLARLH GAKQLMSFSL
     GCTPAVITSD PEVARELLTS PHFANRPLKQ SAQQLLFGRA IGFAPNGGYW RLLRRIASAH
     LFAPRRIAAH EAGRQADVVA MLDDIQKEYH SKGVVRVRRH LQGAALNNIM GSVFGRRFDM
     SHENEEVKKL REMVDEGFQL LGAFNWADHL PWLRPLDPLR IHARCARLVP RVTTFVSNII
     EQHRREEQRR ESGDQCDFVD VLLSLQGEDK LDEEDMIAVL WEMIFRGTDT TALLTEWTMA
     ELVLHPEAQK KAQAELDAVV GHDRSVKDSD IPKLPYIQAV VKEALRMHPP GPLLSWARLS
     TEDVNMGDGM CVPAGTTAMV NMWSITHDPN IWESPYEFRP ERFVVFEGGE EVDVRGNDLR
     LAPFGAGRRV CPGKALGLAT VNLWVAKLLH HFEWLPHAEH PVDLSEVLKL SCEMARPLHC
     VPVTRVPFAK FSD