ID   UB2V2_XENLA             Reviewed;         145 AA.
AC   Q7ZYP0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Ubiquitin-conjugating enzyme E2 variant 2;
GN   Name=ube2v2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has no ubiquitin ligase activity on its own. The ube2v2/ube2n
CC       heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin
CC       chains that are linked through 'Lys-63'. This type of poly-
CC       ubiquitination does not lead to protein degradation by the proteasome.
CC       Mediates transcriptional activation of target genes. Plays a role in
CC       the control of progress through the cell cycle and differentiation.
CC       Plays a role in the error-free DNA repair pathway and contributes to
CC       the survival of cells after DNA damage (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with ube2n. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00388}.
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DR   EMBL; BC042361; AAH42361.1; -; mRNA.
DR   EMBL; BC106303; AAI06304.1; -; mRNA.
DR   RefSeq; NP_001080397.1; NM_001086928.1.
DR   AlphaFoldDB; Q7ZYP0; -.
DR   SMR; Q7ZYP0; -.
DR   DNASU; 380089; -.
DR   GeneID; 380089; -.
DR   KEGG; xla:380089; -.
DR   CTD; 380089; -.
DR   Xenbase; XB-GENE-1015108; ube2v2.S.
DR   OMA; ASWRTEY; -.
DR   OrthoDB; 1507995at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 380089; Expressed in brain and 19 other tissues.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..145
FT                   /note="Ubiquitin-conjugating enzyme E2 variant 2"
FT                   /id="PRO_0000292588"
FT   DOMAIN          10..145
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
SQ   SEQUENCE   145 AA;  16524 MW;  C22842B8D3424F57 CRC64;
     MAVCAGIKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN
     RIYSLRLECG PKYPEAPPTV RFVTKMNMNG INNSNGTVDY RSIPVLAKWQ NSFSIKVLLQ
     ELRRLMMSKE NMKLPQPPEG QTYNN