ID   UBA1L_HUMAN             Reviewed;         381 AA.
AC   F5GYI3;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Ubiquitin-associated protein 1-like;
DE            Short=UBAP-1L;
GN   Name=UBAP1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Melanoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AC013553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC052607; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS53948.1; -.
DR   RefSeq; NP_001157164.1; NM_001163692.1.
DR   AlphaFoldDB; F5GYI3; -.
DR   SMR; F5GYI3; -.
DR   STRING; 9606.ENSP00000454012; -.
DR   PhosphoSitePlus; F5GYI3; -.
DR   BioMuta; UBAP1L; -.
DR   EPD; F5GYI3; -.
DR   MassIVE; F5GYI3; -.
DR   PaxDb; F5GYI3; -.
DR   PeptideAtlas; F5GYI3; -.
DR   PRIDE; F5GYI3; -.
DR   ProteomicsDB; 24749; -.
DR   Antibodypedia; 76928; 6 antibodies from 3 providers.
DR   DNASU; 390595; -.
DR   Ensembl; ENST00000559089.6; ENSP00000454012.1; ENSG00000246922.10.
DR   GeneID; 390595; -.
DR   KEGG; hsa:390595; -.
DR   MANE-Select; ENST00000559089.6; ENSP00000454012.1; NM_001163692.2; NP_001157164.1.
DR   UCSC; uc002aok.4; human.
DR   CTD; 390595; -.
DR   DisGeNET; 390595; -.
DR   GeneCards; UBAP1L; -.
DR   HGNC; HGNC:40028; UBAP1L.
DR   HPA; ENSG00000246922; Group enriched (brain, retina).
DR   neXtProt; NX_F5GYI3; -.
DR   OpenTargets; ENSG00000246922; -.
DR   VEuPathDB; HostDB:ENSG00000246922; -.
DR   eggNOG; ENOG502RVS1; Eukaryota.
DR   GeneTree; ENSGT00390000008092; -.
DR   HOGENOM; CLU_058642_0_0_1; -.
DR   InParanoid; F5GYI3; -.
DR   OMA; CTDILMS; -.
DR   OrthoDB; 908876at2759; -.
DR   PhylomeDB; F5GYI3; -.
DR   PathwayCommons; F5GYI3; -.
DR   BioGRID-ORCS; 390595; 14 hits in 1018 CRISPR screens.
DR   ChiTaRS; UBAP1L; human.
DR   GenomeRNAi; 390595; -.
DR   Pharos; F5GYI3; Tdark.
DR   PRO; PR:F5GYI3; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; F5GYI3; protein.
DR   Bgee; ENSG00000246922; Expressed in right hemisphere of cerebellum and 102 other tissues.
DR   ExpressionAtlas; F5GYI3; baseline and differential.
DR   Genevisible; F5GYI3; HS.
DR   GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR   Gene3D; 1.20.120.1920; -; 1.
DR   InterPro; IPR038870; UBAP1.
DR   InterPro; IPR042575; UBAP1_C.
DR   InterPro; IPR023340; UMA.
DR   PANTHER; PTHR15960; PTHR15960; 1.
DR   PROSITE; PS51497; UMA; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..381
FT                   /note="Ubiquitin-associated protein 1-like"
FT                   /id="PRO_0000413688"
FT   DOMAIN          4..50
FT                   /note="UMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00830"
FT   REGION          87..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..220
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        72
FT                   /note="S -> L (in Ref. 2; BC052607)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   381 AA;  40592 MW;  86B6802D00AF8F20 CRC64;
     MNALDGVPFK LPKGFVIGTE PLPGPELSVP ACGEVLLGSM HDFSLERTAL FWVEAAGQGP
     SPYQCGDPGT ASAPPAWLLL VSPEHGLAPA PTTIRDPEAG HQERPEEEGE DEAEASSGSE
     EEPAPSSLQP GSPASPGPGR RLCSLDVLRG VRLELAGARR RLSEGKLVSR PRALLHGLRG
     HRALSLCPSP AQSPRSASPP GPAPQHPAAP ASPPRPSTAG AIPPLRSHKP TVASLSPYTC
     LPPLGGAPQP LNPHKSHPDT AADLLSALSQ EEQDLIGPVV ALGYPLRRAI IALQKTGRQS
     LSQFLSYLSA CDRLLRQGYE EGLVDEAMEM FQFSESQAGE FLRLWEQFSD MGFQQDRIKE
     VLLVHGNRRE QALEELVACA Q