UBA2C_ARATH
ID UBA2C_ARATH Reviewed; 404 AA.
AC Q9LKA4;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=UBP1-associated protein 2C;
GN Name=UBA2C; OrderedLocusNames=At3g15010; ORFNames=K15M2.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=18278441; DOI=10.1007/s11103-008-9302-z;
RA Bove J., Kim C.Y., Gibson C.A., Assmann S.M.;
RT "Characterization of wound-responsive RNA-binding proteins and their splice
RT variants in Arabidopsis.";
RL Plant Mol. Biol. 67:71-88(2008).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=18705666; DOI=10.1111/j.1469-8137.2008.02557.x;
RA Kim C.Y., Bove J., Assmann S.M.;
RT "Overexpression of wound-responsive RNA-binding proteins induces leaf
RT senescence and hypersensitive-like cell death.";
RL New Phytol. 180:57-70(2008).
CC -!- FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein
CC that acts as component of a complex regulating the turnover of mRNAs in
CC the nucleus. Binds with high affinity to RNA molecules that contain U-
CC rich sequences in 3'-UTRs. May function in complex with UBP1 and
CC contribute to the stabilization of mRNAs in the nucleus (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18278441,
CC ECO:0000269|PubMed:18705666}. Note=Mainly localized into nuclear
CC speckles.
CC -!- TISSUE SPECIFICITY: Expressed in root apical and lateral meristems,
CC young leaves and embryos. {ECO:0000269|PubMed:18278441}.
CC -!- INDUCTION: By wounding. {ECO:0000269|PubMed:18278441}.
CC -!- MISCELLANEOUS: Plants over-expressing UB2A1 display severe growth
CC defects consisting of premature cell death and chlorosis.
CC {ECO:0000305|PubMed:18705666}.
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DR EMBL; AP000370; BAA97064.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75602.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75603.1; -; Genomic_DNA.
DR EMBL; AY063846; AAL36202.1; -; mRNA.
DR EMBL; AY091228; AAM14167.1; -; mRNA.
DR EMBL; AK316731; BAH19456.1; -; mRNA.
DR RefSeq; NP_188119.1; NM_112363.4.
DR RefSeq; NP_974317.1; NM_202588.2.
DR AlphaFoldDB; Q9LKA4; -.
DR SMR; Q9LKA4; -.
DR BioGRID; 6064; 3.
DR IntAct; Q9LKA4; 3.
DR STRING; 3702.AT3G15010.2; -.
DR PaxDb; Q9LKA4; -.
DR PRIDE; Q9LKA4; -.
DR ProteomicsDB; 228597; -.
DR EnsemblPlants; AT3G15010.1; AT3G15010.1; AT3G15010.
DR EnsemblPlants; AT3G15010.2; AT3G15010.2; AT3G15010.
DR GeneID; 820730; -.
DR Gramene; AT3G15010.1; AT3G15010.1; AT3G15010.
DR Gramene; AT3G15010.2; AT3G15010.2; AT3G15010.
DR KEGG; ath:AT3G15010; -.
DR Araport; AT3G15010; -.
DR TAIR; locus:2086325; AT3G15010.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_012062_1_6_1; -.
DR InParanoid; Q9LKA4; -.
DR OMA; HNHPLNS; -.
DR OrthoDB; 1202220at2759; -.
DR PhylomeDB; Q9LKA4; -.
DR PRO; PR:Q9LKA4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LKA4; baseline and differential.
DR Genevisible; Q9LKA4; AT.
DR GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0008219; P:cell death; IMP:TAIR.
DR GO; GO:0006952; P:defense response; IMP:TAIR.
DR GO; GO:0009693; P:ethylene biosynthetic process; IMP:TAIR.
DR GO; GO:0010150; P:leaf senescence; IMP:TAIR.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..404
FT /note="UBP1-associated protein 2C"
FT /id="PRO_0000425442"
FT DOMAIN 75..152
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 167..248
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 41780 MW; 867DCDA90A0DFEB2 CRC64;
MDMMKKRKLD ENGNGLNTNG GGTIGPTRLS PQDARKIIER FTTDQLLDLL QEAIVRHPDV
LESVRLTADS DISQRKLFIR GLAADTTTEG LRSLFSSYGD LEEAIVILDK VTGKSKGYGF
VTFMHVDGAL LALKEPSKKI DGRVTVTQLA ASGNQGTGSQ IADISMRKIY VANVPFDMPA
DRLLNHFMAY GDVEEGPLGF DKVTGKSRGF ALFVYKTAEG AQAALADPVK VIDGKHLNCK
LAVDGKKGGK PGMPQAQDGG SGHGHVHGEG MGMVRPAGPY GAAGGISAYG GYSGGPPAHH
MNSTHSSMGV GSAGYGGHYG GYGGPGGTGV YGGLGGGYGG PGTGSGQYRM PPSSMPGGGG
YPESGHYGLS SSAGYPGQHH QAVGTSPVPR VPHGGMYPNG PPNY
