ID   UBAA_STRUB              Reviewed;          70 AA.
AC   A9Q0M7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Bacteriocin ubericin-A;
DE   Flags: Precursor;
GN   Name=ubaA;
OS   Streptococcus uberis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1349;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 22-61, DISULFIDE
RP   BOND, AND MASS SPECTROMETRY.
RC   STRAIN=E;
RX   PubMed=17933926; DOI=10.1128/aem.01818-07;
RA   Heng N.C.K., Burtenshaw G.A., Jack R.W., Tagg J.R.;
RT   "Ubericin A, a class IIa bacteriocin produced by Streptococcus uberis.";
RL   Appl. Environ. Microbiol. 73:7763-7766(2007).
CC   -!- FUNCTION: Heat-stable antibiotic with bacteriolytic activity against
CC       Listeria spp., E.hirae, E.faecalis ATCC 19433, S.bovis 83, S.uberis 42
CC       and L.lactis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The disulfide bond is essential for the activity.
CC   -!- MASS SPECTROMETRY: Mass=5270.5; Mass_error=5.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17933926};
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC       {ECO:0000305}.
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DR   EMBL; EF203953; ABQ23939.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9Q0M7; -.
DR   SMR; A9Q0M7; -.
DR   TCDB; 1.C.24.1.11; the pediocin (pediocin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.130; -; 1.
DR   InterPro; IPR002633; Bacteriocin_IIa.
DR   InterPro; IPR023384; Bacteriocin_IIa_CS.
DR   InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR   Pfam; PF01721; Bacteriocin_II; 1.
DR   PROSITE; PS60030; BACTERIOCIN_IIA; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:17933926"
FT   CHAIN           22..70
FT                   /note="Bacteriocin ubericin-A"
FT                   /id="PRO_5000298104"
FT   DISULFID        32..37
FT                   /evidence="ECO:0000269|PubMed:17933926"
SQ   SEQUENCE   70 AA;  7681 MW;  A0D25369999041FF CRC64;
     MNTIEKFENI KLFSLKKIIG GKTVNYGNGL YCNQKKCWVN WSETATTIVN NSIMNGLTGG
     NAGWHSGGRA