ID   UBAC1_XENTR             Reviewed;         406 AA.
AC   Q28DG7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Ubiquitin-associated domain-containing protein 1;
DE            Short=UBA domain-containing protein 1;
DE   AltName: Full=E3 ubiquitin-protein ligase subunit KPC2;
DE   AltName: Full=Kip1 ubiquitination-promoting complex protein 2;
GN   Name=ubac1; Synonyms=kpc2, ubadc1; ORFNames=TEgg011a06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-catalytic subunit of the KPC complex that acts as E3
CC       ubiquitin-protein ligase. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the KPC complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CR855524; CAJ81848.1; -; mRNA.
DR   RefSeq; NP_001016826.1; NM_001016826.2.
DR   AlphaFoldDB; Q28DG7; -.
DR   SMR; Q28DG7; -.
DR   STRING; 8364.ENSXETP00000053515; -.
DR   PRIDE; Q28DG7; -.
DR   GeneID; 549580; -.
DR   KEGG; xtr:549580; -.
DR   CTD; 10422; -.
DR   Xenbase; XB-GENE-997434; ubac1.
DR   eggNOG; ENOG502QQQ6; Eukaryota.
DR   InParanoid; Q28DG7; -.
DR   OrthoDB; 1163759at2759; -.
DR   Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd14303; UBA1_KPC2; 1.
DR   CDD; cd14304; UBA2_KPC2; 1.
DR   InterPro; IPR006636; STI1_HS-bd.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR041926; UBA1_UBAC1.
DR   InterPro; IPR041927; UBA2_UBAC1.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF00627; UBA; 2.
DR   SMART; SM00727; STI1; 1.
DR   SMART; SM00165; UBA; 2.
DR   SUPFAM; SSF46934; SSF46934; 2.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50030; UBA; 2.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..406
FT                   /note="Ubiquitin-associated domain-containing protein 1"
FT                   /id="PRO_0000250453"
FT   DOMAIN          14..98
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   DOMAIN          186..231
FT                   /note="UBA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   DOMAIN          289..329
FT                   /note="UBA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   DOMAIN          354..393
FT                   /note="STI1"
FT   REGION          95..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  45374 MW;  F9C0A9DE7C1399FD CRC64;
     MFVQEEKIFA GKGLRLHICS LDGAEWLEEV TEEITVEKLK EKCLKHCSHG SLEDPKSLTH
     HKLVHASSER VLSDTKTLAE ENLQDNDVLL LVKKRAPPPT PKMAEVSADE KRKQDQKAPD
     KDAILKATAG LPARSTDRTV AQHNMRDFQT ELRKILVSLI EVAQKLLALN PDAIELFKKA
     NAMLDEDDED RVDEVALRQL TEMGFPESRA VKALRLNHMS VTQAMEWLIE HADDPAADAP
     LPCENSSEAA GGLATGEAET KPTLGAGAED PKDELTEIFK KIRRKREFRP DPRAVIALME
     MGFDEKEVID ALRVNNNQQD AACEWLLGDR KPSPEDLDKG IDTTSPLFQA ILDNPVVQLG
     LTNPKTLLAF EDMLENPLNS TQWMNDPETG PVMLQISRIF QTLNRT