UBAC2_CHICK
ID UBAC2_CHICK Reviewed; 344 AA.
AC Q5ZJQ8;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Ubiquitin-associated domain-containing protein 2;
DE Short=UBA domain-containing protein 2;
DE AltName: Full=Phosphoglycerate dehydrogenase-like protein 1;
DE Flags: Precursor;
GN Name=UBAC2; Synonyms=PHGDHL1; ORFNames=RCJMB04_16f18;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Restricts trafficking of FAF2 from the endoplasmic reticulum
CC to lipid droplets (By similarity). May negatively regulate the
CC canonical Wnt signaling pathway in the lymphocytes (By similarity).
CC {ECO:0000250|UniProtKB:Q8NBM4}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8NBM4}; Multi-pass membrane protein
CC {ECO:0000255}.
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DR EMBL; AJ720376; CAG32035.1; -; mRNA.
DR RefSeq; NP_001006268.1; NM_001006268.1.
DR AlphaFoldDB; Q5ZJQ8; -.
DR SMR; Q5ZJQ8; -.
DR STRING; 9031.ENSGALP00000027219; -.
DR PaxDb; Q5ZJQ8; -.
DR Ensembl; ENSGALT00000058077; ENSGALP00000049996; ENSGALG00000016880.
DR GeneID; 418778; -.
DR KEGG; gga:418778; -.
DR CTD; 337867; -.
DR VEuPathDB; HostDB:geneid_418778; -.
DR eggNOG; KOG4463; Eukaryota.
DR GeneTree; ENSGT00950000182999; -.
DR HOGENOM; CLU_057710_0_0_1; -.
DR InParanoid; Q5ZJQ8; -.
DR OMA; KVHQVLC; -.
DR OrthoDB; 975575at2759; -.
DR PhylomeDB; Q5ZJQ8; -.
DR PRO; PR:Q5ZJQ8; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000016880; Expressed in kidney and 13 other tissues.
DR ExpressionAtlas; Q5ZJQ8; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd14305; UBA_UBAC2; 1.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041928; UBA_UBAC2.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR PROSITE; PS50030; UBA; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Wnt signaling pathway.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..344
FT /note="Ubiquitin-associated domain-containing protein 2"
FT /id="PRO_0000280757"
FT TOPO_DOM 35..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 304..344
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT REGION 284..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 344 AA; 39225 MW; 9CCB8A5F8CD4A219 CRC64;
MFTSTGSNGL YKAPLSKSLL LVPSAISILL TLLFQHYQKF FAYNLQAIKE DFQIWRLVCG
RVICLDLKDT FCSSLLIYNF RIFERRYGSR KFSSFLLGAW TLSALFDLLL VEAAQYVFGI
TINSLPSGFL GPVFALFVPF YCSIPRVQVT QVLGYFSITN KTLVYILGLQ LLTSGSYIWI
LALSGLISGI CYNSSILKVH RILCVPSWVA KIFSWTLEPI FSSAEPTNEI RVGMGATVDI
QRQQRMELLD RQIMMSQVAQ MRRQRQQQGG MINWNRLFPP LRHRHNENYQ DHHPSDQDTP
PPTEVSEEQV ARLMEMGFSR GDALEALRAS NNDLNVATNF LLQH
