ID   UBAC2_MACFA             Reviewed;         345 AA.
AC   Q4R910;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Ubiquitin-associated domain-containing protein 2;
DE            Short=UBA domain-containing protein 2;
DE   AltName: Full=Phosphoglycerate dehydrogenase-like protein 1;
DE   Flags: Precursor;
GN   Name=UBAC2; Synonyms=PHGDHL1; ORFNames=QtsA-10993;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Restricts trafficking of FAF2 from the endoplasmic reticulum
CC       to lipid droplets (By similarity). In association with LMBR1L and E3
CC       ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt
CC       signaling pathway in the lymphocytes by promoting the ubiquitin-
CC       mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By
CC       similarity). {ECO:0000250|UniProtKB:Q8NBM4}.
CC   -!- SUBUNIT: Interacts with LMBR1L, FAF2, AMFR and VCP (By similarity).
CC       {ECO:0000250|UniProtKB:Q8R1K1}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8NBM4}; Multi-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; AB168287; BAE00411.1; -; mRNA.
DR   RefSeq; NP_001270306.1; NM_001283377.1.
DR   AlphaFoldDB; Q4R910; -.
DR   SMR; Q4R910; -.
DR   STRING; 9541.XP_005586215.1; -.
DR   GeneID; 101866026; -.
DR   CTD; 337867; -.
DR   VEuPathDB; HostDB:ENSMFAG00000033588; -.
DR   eggNOG; KOG4463; Eukaryota.
DR   OMA; KVHQVLC; -.
DR   OrthoDB; 975575at2759; -.
DR   Proteomes; UP000233100; Chromosome 17.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd14305; UBA_UBAC2; 1.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR041928; UBA_UBAC2.
DR   Pfam; PF00627; UBA; 1.
DR   SMART; SM00165; UBA; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS50030; UBA; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Wnt signaling pathway.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..345
FT                   /note="Ubiquitin-associated domain-containing protein 2"
FT                   /id="PRO_0000280755"
FT   TOPO_DOM        36..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..163
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        185..345
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          305..345
FT                   /note="UBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   345 AA;  39046 MW;  E3AD069B1E2FB5C4 CRC64;
     MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKL FVYDLHAVKN DFQIWRLICG
     RIICLDLKDT FCSSLLIYNF RIFERRYGSR KFASFLLGSW VLSALFDFLL VEAMQYFFGI
     TAASNLPSGF LAPVFALFVP FYCSIPRVQV AQILGPLSIT NKTLIYILGL QLFTSGSYIW
     IVAISGLMSG LCYNSKMFQV HQVLCIPSWM AKFFSWTLEP IFSSSEPTSE ARIGMGATLD
     IQRQQRMELL DRQLMFSQFA QGRRQRQQQG GMINWNRLFP PLRQRQNVNY QGGRQSEPAA
     PPPLEVSEEQ VARLMEMGFS RGDALEALRA SNNDLNVATN FLLQH