UBAD1_HUMAN
ID UBAD1_HUMAN Reviewed; 177 AA.
AC Q8TB05; Q71MF6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=UBA-like domain-containing protein 1;
GN Name=UBALD1; Synonyms=FAM100A; ORFNames=PP11303;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix adenocarcinoma, Lung, and Melanoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TB05; O95822-2: MLYCD; NbExp=3; IntAct=EBI-725656, EBI-13315321;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TB05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TB05-2; Sequence=VSP_018573;
CC -!- SIMILARITY: Belongs to the UBALD family. {ECO:0000305}.
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DR EMBL; AF447881; AAQ04656.1; -; mRNA.
DR EMBL; AC023830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012018; AAH12018.1; -; mRNA.
DR EMBL; BC025327; AAH25327.1; -; mRNA.
DR EMBL; BC062534; AAH62534.1; -; mRNA.
DR CCDS; CCDS10518.1; -. [Q8TB05-1]
DR RefSeq; NP_001317396.1; NM_001330467.1.
DR RefSeq; NP_660296.1; NM_145253.2. [Q8TB05-1]
DR AlphaFoldDB; Q8TB05; -.
DR SMR; Q8TB05; -.
DR BioGRID; 125862; 1.
DR IntAct; Q8TB05; 3.
DR STRING; 9606.ENSP00000283474; -.
DR iPTMnet; Q8TB05; -.
DR PhosphoSitePlus; Q8TB05; -.
DR BioMuta; UBALD1; -.
DR DMDM; 74730413; -.
DR EPD; Q8TB05; -.
DR jPOST; Q8TB05; -.
DR MassIVE; Q8TB05; -.
DR MaxQB; Q8TB05; -.
DR PaxDb; Q8TB05; -.
DR PeptideAtlas; Q8TB05; -.
DR PRIDE; Q8TB05; -.
DR ProteomicsDB; 73945; -. [Q8TB05-1]
DR ProteomicsDB; 73946; -. [Q8TB05-2]
DR Antibodypedia; 68119; 10 antibodies from 6 providers.
DR DNASU; 124402; -.
DR Ensembl; ENST00000283474.12; ENSP00000283474.6; ENSG00000153443.13. [Q8TB05-1]
DR Ensembl; ENST00000590891.1; ENSP00000465706.1; ENSG00000153443.13. [Q8TB05-2]
DR GeneID; 124402; -.
DR KEGG; hsa:124402; -.
DR MANE-Select; ENST00000283474.12; ENSP00000283474.6; NM_145253.3; NP_660296.1.
DR UCSC; uc002cwx.2; human. [Q8TB05-1]
DR CTD; 124402; -.
DR GeneCards; UBALD1; -.
DR HGNC; HGNC:29576; UBALD1.
DR HPA; ENSG00000153443; Low tissue specificity.
DR neXtProt; NX_Q8TB05; -.
DR OpenTargets; ENSG00000153443; -.
DR PharmGKB; PA142671782; -.
DR VEuPathDB; HostDB:ENSG00000153443; -.
DR eggNOG; ENOG502S0GG; Eukaryota.
DR GeneTree; ENSGT00390000008825; -.
DR HOGENOM; CLU_1299361_0_0_1; -.
DR InParanoid; Q8TB05; -.
DR OMA; LWTQGPP; -.
DR PhylomeDB; Q8TB05; -.
DR TreeFam; TF329433; -.
DR PathwayCommons; Q8TB05; -.
DR SignaLink; Q8TB05; -.
DR BioGRID-ORCS; 124402; 67 hits in 1069 CRISPR screens.
DR ChiTaRS; UBALD1; human.
DR GenomeRNAi; 124402; -.
DR Pharos; Q8TB05; Tdark.
DR PRO; PR:Q8TB05; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8TB05; protein.
DR Bgee; ENSG00000153443; Expressed in right hemisphere of cerebellum and 130 other tissues.
DR ExpressionAtlas; Q8TB05; baseline and differential.
DR Genevisible; Q8TB05; HS.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR039310; UBALD1/2.
DR PANTHER; PTHR31993; PTHR31993; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..177
FT /note="UBA-like domain-containing protein 1"
FT /id="PRO_0000236079"
FT REGION 89..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..156
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..61
FT /note="MSVNMDELKHQVMINQFVLTAGCAADQAKQLLQAAHWQFETALSAFFQETNI
FT PYSHHHHQM -> MKLLTLQPPGMLWLMERGGLGKPRGPRHRGLLRVRLGRFISRLLLW
FT EPLGGGQAWGSGEGTQSLPRMGQPRISPWEAVGAPPGRGAHPISPLFPSQ (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_018573"
SQ SEQUENCE 177 AA; 18954 MW; 7CCC710752C42712 CRC64;
MSVNMDELKH QVMINQFVLT AGCAADQAKQ LLQAAHWQFE TALSAFFQET NIPYSHHHHQ
MMCTPANTPA TPPNFPDALT MFSRLKASES FHSGGSGSPM AATATSPPPH FPHAATSSSA
ASSWPTAASP PGGPQHHQPQ PPLWTPTPPS PASDWPPLAP QQATSEPRAH PAMEAER
