ID   UBAD2_HUMAN             Reviewed;         164 AA.
AC   Q8IYN6;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=UBA-like domain-containing protein 2;
GN   Name=UBALD2; Synonyms=FAM100B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [3]
RP   STRUCTURE BY NMR OF 1-59.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of the UBA domain in human protein FAM100B.";
RL   Submitted (MAR-2007) to the PDB data bank.
CC   -!- SIMILARITY: Belongs to the UBALD family. {ECO:0000305}.
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DR   EMBL; BC035511; AAH35511.1; -; mRNA.
DR   EMBL; BC060859; AAH60859.1; -; mRNA.
DR   CCDS; CCDS11742.1; -.
DR   RefSeq; NP_872371.1; NM_182565.3.
DR   PDB; 2DZL; NMR; -; A=1-59.
DR   PDBsum; 2DZL; -.
DR   AlphaFoldDB; Q8IYN6; -.
DR   BMRB; Q8IYN6; -.
DR   SMR; Q8IYN6; -.
DR   BioGRID; 129722; 90.
DR   STRING; 9606.ENSP00000331298; -.
DR   iPTMnet; Q8IYN6; -.
DR   PhosphoSitePlus; Q8IYN6; -.
DR   BioMuta; UBALD2; -.
DR   DMDM; 74728359; -.
DR   EPD; Q8IYN6; -.
DR   jPOST; Q8IYN6; -.
DR   MassIVE; Q8IYN6; -.
DR   PaxDb; Q8IYN6; -.
DR   PeptideAtlas; Q8IYN6; -.
DR   PRIDE; Q8IYN6; -.
DR   ProteomicsDB; 71209; -.
DR   Antibodypedia; 19681; 15 antibodies from 8 providers.
DR   DNASU; 283991; -.
DR   Ensembl; ENST00000327490.8; ENSP00000331298.6; ENSG00000185262.9.
DR   GeneID; 283991; -.
DR   KEGG; hsa:283991; -.
DR   MANE-Select; ENST00000327490.8; ENSP00000331298.6; NM_182565.4; NP_872371.1.
DR   UCSC; uc010wsy.2; human.
DR   CTD; 283991; -.
DR   GeneCards; UBALD2; -.
DR   HGNC; HGNC:28438; UBALD2.
DR   HPA; ENSG00000185262; Tissue enhanced (bone).
DR   neXtProt; NX_Q8IYN6; -.
DR   OpenTargets; ENSG00000185262; -.
DR   PharmGKB; PA142671783; -.
DR   VEuPathDB; HostDB:ENSG00000185262; -.
DR   eggNOG; ENOG502S43S; Eukaryota.
DR   GeneTree; ENSGT00390000008825; -.
DR   HOGENOM; CLU_108623_0_1_1; -.
DR   InParanoid; Q8IYN6; -.
DR   OMA; HLHCPQP; -.
DR   OrthoDB; 1581701at2759; -.
DR   PhylomeDB; Q8IYN6; -.
DR   TreeFam; TF329433; -.
DR   PathwayCommons; Q8IYN6; -.
DR   SignaLink; Q8IYN6; -.
DR   BioGRID-ORCS; 283991; 20 hits in 1066 CRISPR screens.
DR   ChiTaRS; UBALD2; human.
DR   EvolutionaryTrace; Q8IYN6; -.
DR   GenomeRNAi; 283991; -.
DR   Pharos; Q8IYN6; Tdark.
DR   PRO; PR:Q8IYN6; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8IYN6; protein.
DR   Bgee; ENSG00000185262; Expressed in bone marrow cell and 178 other tissues.
DR   ExpressionAtlas; Q8IYN6; baseline and differential.
DR   Genevisible; Q8IYN6; HS.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR039310; UBALD1/2.
DR   PANTHER; PTHR31993; PTHR31993; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   CHAIN           2..164
FT                   /note="UBA-like domain-containing protein 2"
FT                   /id="PRO_0000239028"
FT   REGION          128..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   HELIX           6..21
FT                   /evidence="ECO:0007829|PDB:2DZL"
FT   HELIX           25..33
FT                   /evidence="ECO:0007829|PDB:2DZL"
FT   TURN            34..37
FT                   /evidence="ECO:0007829|PDB:2DZL"
FT   HELIX           39..47
FT                   /evidence="ECO:0007829|PDB:2DZL"
SQ   SEQUENCE   164 AA;  17877 MW;  3FF451ADFECBD558 CRC64;
     MSVNMDELRH QVMINQFVLA AGCAADQAKQ LLQAAHWQFE TALSTFFQET NIPNSHHHHQ
     MMCTPSNTPA TPPNFPDALA MFSKLRASEG LQSSNSPMTA AACSPPANFS PFWASSPPSH
     QAPWIPPSSP TTFHHLHRPQ PTWPPGAQQG GAQQKAMAAM DGQR