UBAP2_HUMAN
ID UBAP2_HUMAN Reviewed; 1119 AA.
AC Q5T6F2; Q2M2R4; Q5JV03; Q6PK34; Q8NC94; Q9P237;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Ubiquitin-associated protein 2;
DE Short=UBAP-2;
GN Name=UBAP2 {ECO:0000312|EMBL:AAI11763.1};
GN Synonyms=KIAA1491 {ECO:0000312|EMBL:BAA96015.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC11266.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 511-1119 (ISOFORM 1), AND VARIANTS SER-606 AND
RP VAL-756.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2] {ECO:0000312|EMBL:AL354989}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAI11763.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-669 AND 857-1119 (ISOFORM 1).
RC TISSUE=Brain {ECO:0000312|EMBL:AAH07890.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305, ECO:0000312|EMBL:BAA96015.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 363-1119 (ISOFORM 1), AND VARIANT
RP VAL-756.
RC TISSUE=Brain {ECO:0000269|PubMed:10819331};
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=15144186; DOI=10.1021/ac035352d;
RA Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,
RA Peters E.C.;
RT "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from
RT human T cells using immobilized metal affinity chromatography and tandem
RT mass spectrometry.";
RL Anal. Chem. 76:2763-2772(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
RL Nat. Biotechnol. 23:94-101(2005).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND SER-473, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432; SER-439; SER-473 AND
RP SER-630, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-166, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- INTERACTION:
CC Q5T6F2; Q8WXK3-2: ASB13; NbExp=3; IntAct=EBI-2514383, EBI-12015080;
CC Q5T6F2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-2514383, EBI-1166928;
CC Q5T6F2; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-2514383, EBI-11524452;
CC Q5T6F2; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-2514383, EBI-12809220;
CC Q5T6F2; Q03060-25: CREM; NbExp=3; IntAct=EBI-2514383, EBI-12884642;
CC Q5T6F2; Q15038: DAZAP2; NbExp=3; IntAct=EBI-2514383, EBI-724310;
CC Q5T6F2; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-2514383, EBI-743105;
CC Q5T6F2; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-2514383, EBI-12193763;
CC Q5T6F2; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-2514383, EBI-10242151;
CC Q5T6F2; O75593: FOXH1; NbExp=3; IntAct=EBI-2514383, EBI-1759806;
CC Q5T6F2; O14964: HGS; NbExp=3; IntAct=EBI-2514383, EBI-740220;
CC Q5T6F2; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-2514383, EBI-11955401;
CC Q5T6F2; Q2M1V0: ISX; NbExp=3; IntAct=EBI-2514383, EBI-6426064;
CC Q5T6F2; P0C870: JMJD7; NbExp=3; IntAct=EBI-2514383, EBI-9090173;
CC Q5T6F2; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-2514383, EBI-2556193;
CC Q5T6F2; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-2514383, EBI-11992140;
CC Q5T6F2; P06239-3: LCK; NbExp=3; IntAct=EBI-2514383, EBI-13287659;
CC Q5T6F2; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-2514383, EBI-12025760;
CC Q5T6F2; Q99743: NPAS2; NbExp=3; IntAct=EBI-2514383, EBI-3932727;
CC Q5T6F2; P61970: NUTF2; NbExp=3; IntAct=EBI-2514383, EBI-591778;
CC Q5T6F2; P32242: OTX1; NbExp=3; IntAct=EBI-2514383, EBI-740446;
CC Q5T6F2; Q96CS7: PLEKHB2; NbExp=3; IntAct=EBI-2514383, EBI-373552;
CC Q5T6F2; P67775: PPP2CA; NbExp=3; IntAct=EBI-2514383, EBI-712311;
CC Q5T6F2; Q2L4Q9: PRSS53; NbExp=3; IntAct=EBI-2514383, EBI-18393698;
CC Q5T6F2; P28062-2: PSMB8; NbExp=3; IntAct=EBI-2514383, EBI-372312;
CC Q5T6F2; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-2514383, EBI-740343;
CC Q5T6F2; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-2514383, EBI-372094;
CC Q5T6F2; Q92529: SHC3; NbExp=3; IntAct=EBI-2514383, EBI-79084;
CC Q5T6F2; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-2514383, EBI-11959123;
CC Q5T6F2; Q96A09: TENT5B; NbExp=3; IntAct=EBI-2514383, EBI-752030;
CC Q5T6F2; Q99973: TEP1; NbExp=3; IntAct=EBI-2514383, EBI-947859;
CC Q5T6F2; Q96LM6: TEX37; NbExp=3; IntAct=EBI-2514383, EBI-743976;
CC Q5T6F2; Q92734: TFG; NbExp=3; IntAct=EBI-2514383, EBI-357061;
CC Q5T6F2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-2514383, EBI-11741437;
CC Q5T6F2; Q12888: TP53BP1; NbExp=3; IntAct=EBI-2514383, EBI-396540;
CC Q5T6F2; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-2514383, EBI-8451480;
CC Q5T6F2; Q93009: USP7; NbExp=2; IntAct=EBI-2514383, EBI-302474;
CC Q5T6F2; O95231: VENTX; NbExp=3; IntAct=EBI-2514383, EBI-10191303;
CC Q5T6F2; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-2514383, EBI-2559305;
CC Q5T6F2; Q9BUR4: WRAP53; NbExp=3; IntAct=EBI-2514383, EBI-2563542;
CC Q5T6F2; Q96EJ4; NbExp=3; IntAct=EBI-2514383, EBI-750454;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T6F2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T6F2-2; Sequence=VSP_056073;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI11763.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC11266.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK074884; BAC11266.1; ALT_INIT; mRNA.
DR EMBL; AK125935; BAG54267.1; -; mRNA.
DR EMBL; AL139113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007890; AAH07890.1; -; mRNA.
DR EMBL; BC111762; AAI11763.1; ALT_INIT; mRNA.
DR EMBL; AB040924; BAA96015.1; -; mRNA.
DR CCDS; CCDS6547.1; -. [Q5T6F2-1]
DR CCDS; CCDS75828.1; -. [Q5T6F2-2]
DR RefSeq; NP_001269458.1; NM_001282529.1.
DR RefSeq; NP_001269459.1; NM_001282530.1. [Q5T6F2-2]
DR RefSeq; NP_060919.3; NM_018449.3.
DR AlphaFoldDB; Q5T6F2; -.
DR SMR; Q5T6F2; -.
DR BioGRID; 120938; 133.
DR IntAct; Q5T6F2; 54.
DR MINT; Q5T6F2; -.
DR STRING; 9606.ENSP00000368540; -.
DR GlyGen; Q5T6F2; 36 sites, 2 O-linked glycans (36 sites).
DR iPTMnet; Q5T6F2; -.
DR MetOSite; Q5T6F2; -.
DR PhosphoSitePlus; Q5T6F2; -.
DR BioMuta; UBAP2; -.
DR DMDM; 74745207; -.
DR EPD; Q5T6F2; -.
DR jPOST; Q5T6F2; -.
DR MassIVE; Q5T6F2; -.
DR MaxQB; Q5T6F2; -.
DR PaxDb; Q5T6F2; -.
DR PeptideAtlas; Q5T6F2; -.
DR PRIDE; Q5T6F2; -.
DR ProteomicsDB; 63305; -.
DR ProteomicsDB; 64579; -. [Q5T6F2-1]
DR Antibodypedia; 11067; 80 antibodies from 20 providers.
DR DNASU; 55833; -.
DR Ensembl; ENST00000379238.7; ENSP00000368540.2; ENSG00000137073.24. [Q5T6F2-1]
DR Ensembl; ENST00000682239.1; ENSP00000507293.1; ENSG00000137073.24. [Q5T6F2-1]
DR Ensembl; ENST00000684158.1; ENSP00000508372.1; ENSG00000137073.24. [Q5T6F2-1]
DR GeneID; 55833; -.
DR KEGG; hsa:55833; -.
DR MANE-Select; ENST00000379238.7; ENSP00000368540.2; NM_001370062.2; NP_001356991.2.
DR UCSC; uc003zto.2; human. [Q5T6F2-1]
DR CTD; 55833; -.
DR DisGeNET; 55833; -.
DR GeneCards; UBAP2; -.
DR HGNC; HGNC:14185; UBAP2.
DR HPA; ENSG00000137073; Low tissue specificity.
DR neXtProt; NX_Q5T6F2; -.
DR OpenTargets; ENSG00000137073; -.
DR PharmGKB; PA38379; -.
DR VEuPathDB; HostDB:ENSG00000137073; -.
DR eggNOG; ENOG502QPRH; Eukaryota.
DR GeneTree; ENSGT00390000003453; -.
DR HOGENOM; CLU_009850_0_0_1; -.
DR InParanoid; Q5T6F2; -.
DR OMA; PSQAKHR; -.
DR OrthoDB; 234795at2759; -.
DR PhylomeDB; Q5T6F2; -.
DR TreeFam; TF328468; -.
DR PathwayCommons; Q5T6F2; -.
DR SignaLink; Q5T6F2; -.
DR SIGNOR; Q5T6F2; -.
DR BioGRID-ORCS; 55833; 15 hits in 1085 CRISPR screens.
DR ChiTaRS; UBAP2; human.
DR GeneWiki; UBAP2; -.
DR GenomeRNAi; 55833; -.
DR Pharos; Q5T6F2; Tbio.
DR PRO; PR:Q5T6F2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5T6F2; protein.
DR Bgee; ENSG00000137073; Expressed in sperm and 199 other tissues.
DR ExpressionAtlas; Q5T6F2; baseline and differential.
DR Genevisible; Q5T6F2; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000932; C:P-body; ISS:FlyBase.
DR GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; ISS:FlyBase.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR022166; UBAP2/Lig.
DR Pfam; PF12478; DUF3697; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Methylation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1119
FT /note="Ubiquitin-associated protein 2"
FT /id="PRO_0000270981"
FT DOMAIN 48..92
FT /note="UBA"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..130
FT /evidence="ECO:0000255"
FT COMPBIAS 110..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 166
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 439
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 473
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 630
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..761
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056073"
FT VARIANT 14
FT /note="R -> Q (in dbSNP:rs1785506)"
FT /id="VAR_052677"
FT VARIANT 429
FT /note="P -> L (in dbSNP:rs10971809)"
FT /id="VAR_052678"
FT VARIANT 606
FT /note="N -> S (in dbSNP:rs307658)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_029834"
FT VARIANT 756
FT /note="A -> V (in dbSNP:rs307692)"
FT /evidence="ECO:0000269|PubMed:10819331,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_029835"
FT VARIANT 762
FT /note="M -> I (in dbSNP:rs16935295)"
FT /id="VAR_052679"
SQ SEQUENCE 1119 AA; 117116 MW; 75E7DC542258F82E CRC64;
MMTSVSSDHC RGAREKPQIS AAQSTQPQKQ VVQATAEQMR LAQVIFDKND SDFEAKVKQL
MEVTGKNQDE CIVALHDCNG DVNKAINILL EGNSDTTSWE TVGCKKKNFA KENSENKENR
EKKSEKESSR GRGNNNRKGR GGNRGREFRG EENGIDCNQV DKPSDRGKRA RGRGFGRGRG
RGAGRFSTQG MGTFNPADYS DSTSTDVCGT KLVVWEAAQN GADEGTELAS NTHNIAQDLS
NKSSYGLKGA WKNSVEEWTT EDWTEDLSET KVFTASSAPA ENHILPGQSI DLVALLQKPV
PHSQASEANS FETSQQQGFG QALVFTNSQH NNQMAPGTGS STAVNSCSPQ SLSSVLGSGF
GELAPPKMAN ITSSQILDQL KAPSLGQFTT TPSTQQNSTS HPTTTTSWDL KPPTSQSSVL
SHLDFKSQPE PSPVLSQLSQ RQQHQSQAVT VPPPGLESFP SQAKLRESTP GDSPSTVNKL
LQLPSTTIEN ISVSVHQPQP KHIKLAKRRI PPASKIPASA VEMPGSADVT GLNVQFGALE
FGSEPSLSEF GSAPSSENSN QIPISLYSKS LSEPLNTSLS MTSAVQNSTY TTSVITSCSL
TSSSLNSASP VAMSSSYDQS SVHNRIPYQS PVSSSESAPG TIMNGHGGGR SQQTLDTPKT
TGPPSALPSV SSLPSTTSCT ALLPSTSQHT GDLTSSPLSQ LSSSLSSHQS SLSAHAALSS
STSHTHASVE SASSHQSSAT FSTAATSVSS SASSGASLSS SMNTANSLCL GGTPASASSS
SSRAAPLVTS GKAPPNLPQG VPPLLHNQYL VGPGGLLPAY PIYGYDELQM LQSRLPVDYY
GIPFAAPTAL ASRDGSLANN PYPGDVTKFG RGDSASPAPA TTPAQPQQSQ SQTHHTAQQP
FVNPALPPGY SYTGLPYYTG MPSAFQYGPT MFVPPASAKQ HGVNLSTPTP PFQQASGYGQ
HGYSTGYDDL TQGTAAGDYS KGGYAGSSQA PNKSAGSGPG KGVSVSSSTT GLPDMTGSVY
NKTQTFDKQG FHAGTPPPFS LPSVLGSTGP LASGAAPGYA PPPFLHILPA HQQPHSQLLH
HHLPQDAQSG SGQRSQPSSL QPKSQASKPA YGNSPYWTN
