ID   UBAP2_MOUSE             Reviewed;        1132 AA.
AC   Q91VX2; Q812D6; Q99K40;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Ubiquitin-associated protein 2;
DE            Short=UBAP-2;
DE   AltName: Full=Protein lingerer homolog 1;
DE            Short=mLig-1;
GN   Name=Ubap2 {ECO:0000312|MGI:MGI:1916176};
GN   Synonyms=Lig1 {ECO:0000312|EMBL:AAO23024.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:AAO23024.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12524348; DOI=10.1093/genetics/162.4.1775;
RA   Kuniyoshi H., Baba K., Ueda R., Kondo S., Awano W., Juni N., Yamamoto D.;
RT   "Lingerer, a Drosophila gene involved in initiation and termination of
RT   copulation, encodes a set of novel cytoplasmic proteins.";
RL   Genetics 162:1775-1789(2002).
RN   [2] {ECO:0000312|EMBL:AAH07179.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland {ECO:0000312|EMBL:AAH07179.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15592455; DOI=10.1038/nbt1046;
RA   Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA   Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT   "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
RL   Nat. Biotechnol. 23:94-101(2005).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Liver, Lung, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
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DR   EMBL; AF276965; AAO23024.1; -; mRNA.
DR   EMBL; BC005482; AAH05482.1; -; mRNA.
DR   EMBL; BC007179; AAH07179.1; -; mRNA.
DR   CCDS; CCDS18058.1; -.
DR   RefSeq; NP_081148.1; NM_026872.1.
DR   RefSeq; XP_006538287.1; XM_006538224.1.
DR   AlphaFoldDB; Q91VX2; -.
DR   SMR; Q91VX2; -.
DR   BioGRID; 213121; 6.
DR   IntAct; Q91VX2; 2.
DR   STRING; 10090.ENSMUSP00000030143; -.
DR   iPTMnet; Q91VX2; -.
DR   PhosphoSitePlus; Q91VX2; -.
DR   SwissPalm; Q91VX2; -.
DR   EPD; Q91VX2; -.
DR   jPOST; Q91VX2; -.
DR   MaxQB; Q91VX2; -.
DR   PaxDb; Q91VX2; -.
DR   PRIDE; Q91VX2; -.
DR   ProteomicsDB; 297782; -.
DR   Antibodypedia; 11067; 80 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000030143; ENSMUSP00000030143; ENSMUSG00000028433.
DR   GeneID; 68926; -.
DR   KEGG; mmu:68926; -.
DR   UCSC; uc008sik.1; mouse.
DR   CTD; 55833; -.
DR   MGI; MGI:1916176; Ubap2.
DR   VEuPathDB; HostDB:ENSMUSG00000028433; -.
DR   eggNOG; ENOG502QPRH; Eukaryota.
DR   GeneTree; ENSGT00390000003453; -.
DR   HOGENOM; CLU_009850_0_0_1; -.
DR   InParanoid; Q91VX2; -.
DR   OMA; PSQAKHR; -.
DR   OrthoDB; 234795at2759; -.
DR   PhylomeDB; Q91VX2; -.
DR   TreeFam; TF328468; -.
DR   BioGRID-ORCS; 68926; 3 hits in 73 CRISPR screens.
DR   ChiTaRS; Ubap2; mouse.
DR   PRO; PR:Q91VX2; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q91VX2; protein.
DR   Bgee; ENSMUSG00000028433; Expressed in embryonic post-anal tail and 259 other tissues.
DR   ExpressionAtlas; Q91VX2; baseline and differential.
DR   Genevisible; Q91VX2; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR022166; UBAP2/Lig.
DR   Pfam; PF12478; DUF3697; 1.
DR   SMART; SM00165; UBA; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
PE   1: Evidence at protein level;
KW   Methylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..1132
FT                   /note="Ubiquitin-associated protein 2"
FT                   /id="PRO_0000270982"
FT   DOMAIN          48..92
FT                   /note="UBA"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          95..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          713..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          875..919
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          996..1033
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1040..1059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1087..1132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..404
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        602..639
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        892..914
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        999..1033
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1090..1132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         166
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5T6F2"
FT   MOD_RES         433
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5T6F2"
FT   MOD_RES         440
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5T6F2"
FT   MOD_RES         631
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5T6F2"
FT   CONFLICT        698
FT                   /note="T -> A (in Ref. 1; AAO23024)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1132 AA;  117966 MW;  ECF8E72C9134BB38 CRC64;
     MMTSVSNDRC RGAREKPQMP TAHAAQSQKQ VVQATAEQMR LAQVIFDKND SDFEAKVKQL
     MEVTGKNQDE CIVALHDCNG DVNKAINILL EGNSDTTSWE TVGGKKKNFG RESSENKENR
     EKRTEREASR GRGTNNRKGR GGNRVREFKG EENGIDCSQG DKPAERGKRA RGRGFGRGRG
     RGTGRFSAQS MGTFNPADYS ESMSTDGCGT KLAVWEAAQN GTDEGPEGLA KSHSMSQEPP
     SKSSYGLKGA WKNSVEEWTT EDWTEDLSET KVFTASSAPA ENHVTPGHSI DLVALLHKPA
     PPTQATEVNS FETSQQQGFG QALVFTNSQH NNQMAPGTAN STSASSYSPQ SLSSVLGSGF
     GELPQSNMVN ISNSQILDKL KPPGLSPFPA ASSAQQNDTA SPPATTAAWD LKPSAPQPSV
     LSRLDFKSQP EPSPVLSQLS QRQQHQTQAV SVPPPGLESF SSLAKPREST AGDGPSTVSR
     LLQLPNMTVE NIVSAHQPQP KHIKLPKRRV PPASKVPVSA VEMPGSSDVT GLNVQFGALE
     FGSEPSLSEF GSAASASENS NQIPISLYPK SLSEPLNASF PMTSAVQSST YTTSVVTSST
     LTSSALSSTS PVTTSSSYDQ SSVHTRIAYQ SSASPPDSAP GSVANGHGGG RSQHTVDTTS
     SVPAPKKTDP SALPSVSTLP GPASCTALLP SSAQHTATLP SLTPAAAELS SSPLSQLSSS
     LSGHQNSMTS AHATRSTSTP HTHASVESTA SSAAFSAAAT SAPSAPSSGV VLPGSMSTVS
     SLCLGGTTVS VPSSSTRATA LVTSGKAPPN LPQGVPPLLH NQYLVGPGGL LPAYPIYGYD
     ELQMLQSRLP MDYYGIPFAA PTALASRDGN LANNPYSGDV TKFGRGDSAS PAPPTTPAQA
     QQSQSQTHHT AQQPFLNPGL PPGYSYTGLP YYTGVPSAFQ YGPTMFVPPT SAKQHGVALS
     TPPTPFQQAS GYGQHAYSTG YDDLTQGTAA GDYTKGGYGG SSQAPNKSTG SGPGKGVSVS
     SGTGLPDMTG SVYNKTQTFD KQGFHAGTPP PFSLPSALGS TGPLAPAAAP GYAPAPFLHI
     MPAHQQPHSQ LLHHHLQQDA PSGSGQRSQP SSLQPKSQAS KPTYGSAPYW TN