ID   UBC17_CAEEL             Reviewed;         728 AA.
AC   Q11076;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Probable ubiquitin-conjugating enzyme protein 17;
GN   Name=ubc-17; ORFNames=B0403.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=11806825; DOI=10.1186/gb-2001-3-1-research0002;
RA   Jones D., Crowe E., Stevens T.A., Candido E.P.M.;
RT   "Functional and phylogenetic analysis of the ubiquitylation system in
RT   Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating
RT   enzymes, and ubiquitin-like proteins.";
RL   Genome Biol. 3:RESEARCH0002.1-RESEARCH0002.15(2002).
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00388}.
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DR   EMBL; FO080188; CCD61841.3; -; Genomic_DNA.
DR   PIR; T15350; T15350.
DR   RefSeq; NP_509188.3; NM_076787.3.
DR   AlphaFoldDB; Q11076; -.
DR   SMR; Q11076; -.
DR   STRING; 6239.B0403.2; -.
DR   iPTMnet; Q11076; -.
DR   PaxDb; Q11076; -.
DR   EnsemblMetazoa; B0403.2.1; B0403.2.1; WBGene00006712.
DR   GeneID; 181979; -.
DR   KEGG; cel:CELE_B0403.2; -.
DR   UCSC; B0403.2; c. elegans.
DR   CTD; 181979; -.
DR   WormBase; B0403.2; CE47666; WBGene00006712; ubc-17.
DR   eggNOG; KOG0895; Eukaryota.
DR   GeneTree; ENSGT00940000156126; -.
DR   HOGENOM; CLU_422917_0_0_1; -.
DR   InParanoid; Q11076; -.
DR   OMA; RSRWDIE; -.
DR   OrthoDB; 385948at2759; -.
DR   PhylomeDB; Q11076; -.
DR   PRO; PR:Q11076; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006712; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   CDD; cd00195; UBCc; 1.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   3: Inferred from homology;
KW   Ligase; Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..728
FT                   /note="Probable ubiquitin-conjugating enzyme protein 17"
FT                   /id="PRO_0000082617"
FT   DOMAIN          402..568
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          649..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          709..728
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        652..678
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        713..728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        495
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
SQ   SEQUENCE   728 AA;  83100 MW;  3864BA2D947F7659 CRC64;
     MSSQASQRSS STSAVAQKTR ERRKSKSRRR CWFGCLWLSS RVSLIRSSSR FSRSPEPDES
     LTAIDKVMSI INEKPLKMAH ILKTARFVND VSFSERKQFV ECGVIHHLLE LIGETAISDF
     SASSRSADEQ KRRARRNSSA SLSHKGTGYG TGSTRSRWDI ERTVEEKLIR EEHLTWLLSI
     LNSFMLGWPT TDNLKTKPEE LVHMTEIAIK LIADSSVLSI LEYNLRNDSF FDVSEHIEIY
     QALLETAASM AATPGLVPFL VRPYTSSAKS IAKELIPRFK ENILSIQARW GGTLEETNFR
     MAEFTAKVTL LSDYVINAAR AYEQTLPPEQ RIQTATHRRP SHSGLHSKMQ GPKDDETIYK
     NKMQELQLQT AKFIGDFGKL CVPYVFRKEA KNINPFSPHL RDRTKRIAKE LASIANALPL
     NASNSIYVCY DEGRVDIIKV LISGPDDTPY ANGLFEFDIF FPTGYPFSPP KCAFLTTGSG
     NVRFNPNLYN DGKICLSILG TWEGRPEEKW NPYCSLMQVL VSIQGLIFVK DPYFNEPGFE
     RYQGTDRGDE YSRKYNLQIE HATLNYAIRE QLKKPSEHFK EVIEKHLWLK REAILKQAQA
     WIDNVSNDFG DDKMSKRKDV FAFETGFNPA TQERVIHNLI QELQAMQSPF AKEEAEESER
     LKREQSEKEE KQKKEAAALA EIEREKRELE LDFQRRRSSV LATHVAVIRT QPTGDYSVPS
     VNEPSTSS