C7A13_ARATH
ID C7A13_ARATH Reviewed; 512 AA.
AC Q9LUC8;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Cytochrome P450 72A13;
DE EC=1.14.-.-;
GN Name=CYP72A13; OrderedLocusNames=At3g14660; ORFNames=MIE1.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INDUCTION BY CIS-JASMONE.
RX PubMed=18356298; DOI=10.1073/pnas.0710305105;
RA Bruce T.J., Matthes M.C., Chamberlain K., Woodcock C.M., Mohib A.,
RA Webster B., Smart L.E., Birkett M.A., Pickett J.A., Napier J.A.;
RT "cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of
RT multitrophic interactions with aphids and their parasitoids.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:4553-4558(2008).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: By cis-jasmone. {ECO:0000269|PubMed:18356298}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AB023038; BAB02398.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75552.1; -; Genomic_DNA.
DR EMBL; AY065060; AAL57694.1; -; mRNA.
DR EMBL; BT002745; AAO22574.1; -; mRNA.
DR RefSeq; NP_188084.1; NM_112327.3.
DR AlphaFoldDB; Q9LUC8; -.
DR SMR; Q9LUC8; -.
DR STRING; 3702.AT3G14660.1; -.
DR iPTMnet; Q9LUC8; -.
DR PaxDb; Q9LUC8; -.
DR PRIDE; Q9LUC8; -.
DR ProteomicsDB; 240535; -.
DR EnsemblPlants; AT3G14660.1; AT3G14660.1; AT3G14660.
DR GeneID; 820694; -.
DR Gramene; AT3G14660.1; AT3G14660.1; AT3G14660.
DR KEGG; ath:AT3G14660; -.
DR Araport; AT3G14660; -.
DR TAIR; locus:2089596; AT3G14660.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_5_0_1; -.
DR InParanoid; Q9LUC8; -.
DR OMA; IVHECNR; -.
DR OrthoDB; 825914at2759; -.
DR PhylomeDB; Q9LUC8; -.
DR BioCyc; ARA:AT3G14660-MON; -.
DR PRO; PR:Q9LUC8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUC8; baseline and differential.
DR Genevisible; Q9LUC8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..512
FT /note="Cytochrome P450 72A13"
FT /id="PRO_0000425856"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 460
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 512 AA; 58459 MW; D0AD22A9C907059D CRC64;
MEISVASVTV SVAVVVVSWW VWRTLQRVWL KPKMLESYLR RQGLAGTPYT PLVGDLKRNF
SMLAEARSKP INLTDDITPR IVPYPLQMLK THGRTFFTWF GPIPTITIMD PEQIKEVFNK
VYDFQKAHTF PLGRLIAAGL VSYDGDKWTK HRRIINPAFH LEKIKNMVPA FHQSCSEIVG
EWDKLVTDKQ SSCEVDIWPW LVSMTADVIS RTAFGSSYKE GQRIFELQAE LAQLIIQAFR
KAIIPGYRYF PTKGNRRMKA AAREIKFILR GIVNKRLRAR EAGEAPSDDL LGILLESNLG
QTKGNGMSTE ELMEECKLFY FAGQETTTVL LVWTMVLLSQ HQDWQARARE EVKQVFGDKE
PDAEGLNQLK VMTMILYEVL RLYPPVVQLT RAIHKEMQLG DLTLPGGVQI SLPILLIQRD
RELWGNDAGE FKPDRFKDGL SKATKNQVSF FPFAWGPRIC IGQNFALLEA KMAMTLILRK
FSFELSPSYV HAPYTVLTTH PQFGAPLILH KL
