C7A14_ARATH
ID C7A14_ARATH Reviewed; 512 AA.
AC Q9LUC6;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Cytochrome P450 72A14;
DE EC=1.14.-.-;
GN Name=CYP72A14; OrderedLocusNames=At3g14680; ORFNames=MIE1.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AB023038; BAB02400.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75555.1; -; Genomic_DNA.
DR EMBL; AF367347; AAK32934.1; -; mRNA.
DR EMBL; BT001008; AAN46762.1; -; mRNA.
DR RefSeq; NP_188086.1; NM_112329.4.
DR AlphaFoldDB; Q9LUC6; -.
DR SMR; Q9LUC6; -.
DR STRING; 3702.AT3G14680.1; -.
DR PaxDb; Q9LUC6; -.
DR PRIDE; Q9LUC6; -.
DR ProteomicsDB; 239145; -.
DR EnsemblPlants; AT3G14680.1; AT3G14680.1; AT3G14680.
DR GeneID; 820696; -.
DR Gramene; AT3G14680.1; AT3G14680.1; AT3G14680.
DR KEGG; ath:AT3G14680; -.
DR Araport; AT3G14680; -.
DR TAIR; locus:2089621; AT3G14680.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_5_0_1; -.
DR InParanoid; Q9LUC6; -.
DR OMA; WSSEANV; -.
DR OrthoDB; 825914at2759; -.
DR PhylomeDB; Q9LUC6; -.
DR BioCyc; ARA:AT3G14680-MON; -.
DR PRO; PR:Q9LUC6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUC6; baseline and differential.
DR Genevisible; Q9LUC6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..512
FT /note="Cytochrome P450 72A14"
FT /id="PRO_0000425857"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 460
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 512 AA; 58507 MW; D667E3797328ABDA CRC64;
MEISVSSVTF SLAVVVVSWW VWRTLKWVWF TPKMLERSLR RQGLSGTSYT PLIGDFKKMI
SMFIEATSKP IKPTDDITPR VMPHPLQMLK THGRTNLTWF GPIPTITIMD PEQIKEVFNK
VYDFQKAHTF PLSKILGTGL VSYDGDKWAQ HRRIINPAFH LEKIKNMVHV FHESCSELVG
EWDKLVSDKG SSCEVDVWPG LTSMTADVIS RTAFGSSYRE GHRIFELQAE LAQLVMQAFQ
KFFIPGYIYL PTKGNRRMKT AAREIQDILR GIINKRERAR ESGEAPSEDL LGILLESNLG
QTEGNGMSTE DMMEECKLFY LAGQETTSVL LVWTMVLLSQ HQDWQARARE EVKQVFGDKQ
PDTEGLNQLK VMTMILYEVL RLYPPVVQLT RAIHKEMKLG DLTLPGGVQI SLPVLLVHRD
TELWGNDAGE FKPERFKDGL SKATKNQVSF FPFAWGPRIC IGQNFTLLEA KMAMSLILQR
FSFELSPSYV HAPYTIITLY PQFGAHLMLH KL
