ID   UBE2V_DICDI             Reviewed;         138 AA.
AC   Q54D06;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Probable ubiquitin-conjugating enzyme E2 variant;
GN   Name=ube2v; ORFNames=DDB_G0292596;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Has no ubiquitin ligase activity on its own. The ube2v/ube2n
CC       heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin
CC       chains that are linked through 'Lys-63'. This type of poly-
CC       ubiquitination does not lead to protein degradation by the proteasome.
CC       Mediates transcriptional activation of target genes. Plays a role in
CC       the control of progress through the cell cycle and differentiation.
CC       Plays a role in the error-free DNA repair pathway and contributes to
CC       the survival of cells after DNA damage (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with ube2n. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00388}.
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DR   EMBL; AAFI02000194; EAL61101.1; -; Genomic_DNA.
DR   RefSeq; XP_629514.1; XM_629512.1.
DR   AlphaFoldDB; Q54D06; -.
DR   SMR; Q54D06; -.
DR   STRING; 44689.DDB0237669; -.
DR   PaxDb; Q54D06; -.
DR   EnsemblProtists; EAL61101; EAL61101; DDB_G0292596.
DR   GeneID; 8628765; -.
DR   KEGG; ddi:DDB_G0292596; -.
DR   dictyBase; DDB_G0292596; ube2v.
DR   eggNOG; KOG0896; Eukaryota.
DR   HOGENOM; CLU_063065_4_0_1; -.
DR   InParanoid; Q54D06; -.
DR   OMA; NLPCVDQ; -.
DR   PhylomeDB; Q54D06; -.
DR   Reactome; R-DDI-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR   Reactome; R-DDI-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-DDI-9020702; Interleukin-1 signaling.
DR   Reactome; R-DDI-9646399; Aggrephagy.
DR   Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q54D06; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006301; P:postreplication repair; IBA:GO_Central.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..138
FT                   /note="Probable ubiquitin-conjugating enzyme E2 variant"
FT                   /id="PRO_0000328619"
FT   DOMAIN          5..138
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
SQ   SEQUENCE   138 AA;  15495 MW;  118CB6E5E76266B2 CRC64;
     MTTIPRNFVL LEELESGEKS TGDGTISYGL ESPDDILLSS WIGTIIGPQN TPFDNRFYSL
     KLYCDKDYPN KPPTVRFTTK INIGCVNQQN GVVDPKNLPI LSNWTSKNRI QNILSELRRE
     MSSSSNKKLV QPPEGANF