ID   UBE2Z_XENLA             Reviewed;         313 AA.
AC   Q6PCF7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Ubiquitin-conjugating enzyme E2 Z;
DE            EC=2.3.2.23;
DE   AltName: Full=E2 ubiquitin-conjugating enzyme Z;
DE   AltName: Full=Ubiquitin carrier protein Z;
DE   AltName: Full=Ubiquitin-protein ligase Z;
GN   Name=ube2z;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the covalent attachment of ubiquitin to other
CC       proteins. May be involved in apoptosis regulation.
CC       {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine +
CC         [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-
CC         activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-
CC         conjugating enzyme]-L-cysteine.; EC=2.3.2.23;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00388};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H832}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9H832}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH59343.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC059343; AAH59343.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001080034.2; NM_001086565.1.
DR   AlphaFoldDB; Q6PCF7; -.
DR   SMR; Q6PCF7; -.
DR   MaxQB; Q6PCF7; -.
DR   DNASU; 379726; -.
DR   GeneID; 379726; -.
DR   KEGG; xla:379726; -.
DR   CTD; 379726; -.
DR   Xenbase; XB-GENE-990991; ube2z.S.
DR   OMA; CFDYHSL; -.
DR   OrthoDB; 1404665at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 379726; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IEA:UniProtKB-EC.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd00195; UBCc; 1.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..313
FT                   /note="Ubiquitin-conjugating enzyme E2 Z"
FT                   /id="PRO_0000280519"
FT   DOMAIN          58..212
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          283..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        147
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
SQ   SEQUENCE   313 AA;  35110 MW;  E9D3186D6AFAA73D CRC64;
     MAESPAAEAI ILPGAAAGGG VVPHLSGLQT PGTSLLTTSS VWDPSASADW DNERASTQCV
     LRIKRDIMSI YKEPPPGMFV VPDPHDMTKI HALITGPFDT PYEGGFFLFL FRCPPDYPIH
     PPRVKLMTTG NNTVRFNPNF YRNGKVCLSI LGTWTGPAWS PAQSLSSVLI SIQSLMTENP
     YHNEPGFEQE RHSGDSKNYN ECIRHETIRV AVCEMLEGKC QCPDALRSVM EKSFMEYYDF
     YEAVCKDRFH LQGQNMQDPF GEKRGHFDYQ SLLSRLQTIH QRVREKHRRE TVDIDSDSSS
     SETETDTQGS SNP