ID   UBF1A_XENLA             Reviewed;         677 AA.
AC   P25979;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Nucleolar transcription factor 1-A;
DE   AltName: Full=Upstream-binding factor 1-A;
DE            Short=UBF-1-A;
DE            Short=xUBF-1;
GN   Name=ubtf-a; Synonyms=ubf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2041774; DOI=10.1093/nar/19.9.2331;
RA   Bachvarov D.R., Moss T.;
RT   "The RNA polymerase I transcription factor xUBF contains 5 tandemly
RT   repeated HMG homology boxes.";
RL   Nucleic Acids Res. 19:2331-2335(1991).
CC   -!- FUNCTION: UBF recognizes the ribosomal RNA gene promotor and activates
CC       transcription mediated by RNA polymerase I through cooperative
CC       interactions with the species-specific factor SL1. It binds
CC       specifically to the upstream control element.
CC   -!- SUBUNIT: XUBF consists of 2 polypeptides of 82 and 85 kDa, encoded by
CC       the same or closely related genes.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X57201; CAA40487.1; -; mRNA.
DR   PIR; S15667; S15667.
DR   PIR; S78455; S78455.
DR   RefSeq; NP_001095257.1; NM_001101787.1.
DR   AlphaFoldDB; P25979; -.
DR   SMR; P25979; -.
DR   BioGRID; 100642; 2.
DR   IntAct; P25979; 1.
DR   GeneID; 399317; -.
DR   KEGG; xla:399317; -.
DR   CTD; 399317; -.
DR   Xenbase; XB-GENE-6254049; ubtf.L.
DR   OMA; IMREYMQ; -.
DR   OrthoDB; 1237679at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 399317; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; ISS:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 5.
DR   InterPro; IPR029215; HMG_box_5.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00505; HMG_box; 2.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   Pfam; PF14887; HMG_box_5; 1.
DR   SMART; SM00398; HMG; 5.
DR   SUPFAM; SSF47095; SSF47095; 5.
DR   PROSITE; PS50118; HMG_BOX_2; 5.
DR   PROSITE; PS50090; MYB_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..677
FT                   /note="Nucleolar transcription factor 1-A"
FT                   /id="PRO_0000048628"
FT   DOMAIN          14..76
FT                   /note="Myb-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   DNA_BIND        112..180
FT                   /note="HMG box 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        196..264
FT                   /note="HMG box 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        298..362
FT                   /note="HMG box 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        400..467
FT                   /note="HMG box 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        486..552
FT                   /note="HMG box 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          376..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          557..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..198
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..659
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   677 AA;  79168 MW;  91340A46AFE7A702 CRC64;
     MNGAAGGVTQ AKMTAPKDQD PWSQDEMLTL IQTMKTLLPS QDNSKFKTTE SHLDWNKLAF
     KNYSGSMCRQ KWMEISNEVR KFRTLSELIL DAEEHVRHPY KGKKLKKHPE FPKKPLTPYF
     RFFMEKRAKY AKLHPEMSNL DLTKILSKKY KELPEKKKMK YIQDFQREKL EFERNLARFR
     EEHPDLMQNP KKSDVPEKPK TPQQLWYNHE RKVYLKLHAD ASTKDVKDAL GKQWSQLTDK
     KRLKWIHKAL EQRKQYEGIM REYMQKHPEL NIAEEGITRS TLTKAERQLK DKFDGRPTKP
     PPNSYSMYCA ELMANMKDVP STERMVLCSQ RWKLLSQKEK DAYNKKCEQR KKDYEVELMR
     FLESLPEEEQ QRVLAEEKMV RSRSGQADKK KAADERAKLP ETPKTAEEIW QQSVIGDYLA
     RFKNDRAKAL KSMEGTWLNM EKKEKIMWIK KAAEDQKRYE RELSDMRATP TPTTAGKKVK
     FLGEPKKAPM NGYQKFSQEL LSNGELNHLP LKERMVEIGS RWHRISPSQK DYYKKLAEDQ
     QRVYRTQFDT WMKGLSSQDR AAYKEQNSNK RKSTAKIQVP VAKPKLVAQS KSDDDDEDDD
     DDEDEDDDDD EDEDKEDSSE DGDSSESSSD EDSEDGEENE DEEGEEDEDE EEDDDDNESG
     SSSSSSSSAD SSDSDSN