UBFD1_HUMAN
ID UBFD1_HUMAN Reviewed; 309 AA.
AC O14562; A8MW58; D3DWF2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Ubiquitin domain-containing protein UBFD1;
DE AltName: Full=Ubiquitin-binding protein homolog;
GN Name=UBFD1; Synonyms=UBPH;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND INTERACTION WITH POLYUBIQUITIN.
RX PubMed=19285159; DOI=10.1016/j.bbapap.2009.02.013;
RA Fenner B.J., Scannell M., Prehn J.H.;
RT "Identification of polyubiquitin binding proteins involved in NF-kappaB
RT signaling using protein arrays.";
RL Biochim. Biophys. Acta 1794:1010-1016(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May play a role as NF-kappa-B regulator.
CC {ECO:0000269|PubMed:19285159}.
CC -!- SUBUNIT: Binds polyubiquitin.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC05812.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW55818.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW55819.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK092696; BAG52599.1; -; mRNA.
DR EMBL; AC002400; AAC05812.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC008870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471145; EAW55818.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471145; EAW55819.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS10613.2; -.
DR PIR; T00742; T00742.
DR RefSeq; NP_061989.2; NM_019116.2.
DR AlphaFoldDB; O14562; -.
DR SMR; O14562; -.
DR BioGRID; 121034; 55.
DR IntAct; O14562; 4.
DR MINT; O14562; -.
DR STRING; 9606.ENSP00000379217; -.
DR GlyGen; O14562; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O14562; -.
DR MetOSite; O14562; -.
DR PhosphoSitePlus; O14562; -.
DR BioMuta; UBFD1; -.
DR EPD; O14562; -.
DR jPOST; O14562; -.
DR MassIVE; O14562; -.
DR MaxQB; O14562; -.
DR PaxDb; O14562; -.
DR PeptideAtlas; O14562; -.
DR PRIDE; O14562; -.
DR ProteomicsDB; 48089; -.
DR Antibodypedia; 55161; 149 antibodies from 22 providers.
DR DNASU; 56061; -.
DR Ensembl; ENST00000395878.8; ENSP00000379217.3; ENSG00000103353.16.
DR GeneID; 56061; -.
DR KEGG; hsa:56061; -.
DR MANE-Select; ENST00000395878.8; ENSP00000379217.3; NM_019116.3; NP_061989.2.
DR UCSC; uc002dlv.4; human.
DR CTD; 56061; -.
DR GeneCards; UBFD1; -.
DR HGNC; HGNC:30565; UBFD1.
DR HPA; ENSG00000103353; Tissue enhanced (skeletal).
DR neXtProt; NX_O14562; -.
DR OpenTargets; ENSG00000103353; -.
DR PharmGKB; PA162407893; -.
DR VEuPathDB; HostDB:ENSG00000103353; -.
DR eggNOG; KOG1872; Eukaryota.
DR GeneTree; ENSGT00390000012857; -.
DR InParanoid; O14562; -.
DR OMA; YHIMGIQ; -.
DR OrthoDB; 1199366at2759; -.
DR PhylomeDB; O14562; -.
DR TreeFam; TF333280; -.
DR PathwayCommons; O14562; -.
DR SignaLink; O14562; -.
DR BioGRID-ORCS; 56061; 25 hits in 1077 CRISPR screens.
DR ChiTaRS; UBFD1; human.
DR GenomeRNAi; 56061; -.
DR Pharos; O14562; Tdark.
DR PRO; PR:O14562; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; O14562; protein.
DR Bgee; ENSG00000103353; Expressed in secondary oocyte and 182 other tissues.
DR ExpressionAtlas; O14562; baseline and differential.
DR Genevisible; O14562; HS.
DR GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR039120; UBFD1.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR PANTHER; PTHR16470; PTHR16470; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..309
FT /note="Ubiquitin domain-containing protein UBFD1"
FT /id="PRO_0000283075"
FT DOMAIN 84..159
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 33382 MW; 2608827C4A7AFED5 CRC64;
MAAAGAPDGM EEPGMDTEAE TVATEAPARP VNCLEAEAAA GAAAEDSGAA RGSLQPAPAQ
PPGDPAAQAS VSNGEDAGGG AGRELVDLKI IWNKTKHDVK FPLDSTGSEL KQKIHSITGL
PPAMQKVMYK GLVPEDKTLR EIKVTSGAKI MVVGSTINDV LAVNTPKDAA QQDAKAEENK
KEPLCRQKQH RKVLDKGKPE DVMPSVKGAQ ERLPTVPLSG MYNKSGGKVR LTFKLEQDQL
WIGTKERTEK LPMGSIKNVV SEPIEGHEDY HMMAFQLGPT EASYYWVYWV PTQYVDAIKD
TVLGKWQYF
