UBFL1_HUMAN
ID UBFL1_HUMAN Reviewed; 393 AA.
AC P0CB47; C9JMX8;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Upstream-binding factor 1-like protein 1 {ECO:0000305};
GN Name=UBTFL1 {ECO:0000312|HGNC:HGNC:14533}; Synonyms=C11orf27;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- FUNCTION: Essential for proliferation of the inner cell mass and
CC trophectodermal cells in peri-implantation development.
CC {ECO:0000250|UniProtKB:Q3USZ2}.
CC -!- INTERACTION:
CC P0CB47; Q5T5X7: BEND3; NbExp=3; IntAct=EBI-17208936, EBI-1211496;
CC P0CB47; Q3SXR2: C3orf36; NbExp=3; IntAct=EBI-17208936, EBI-18036948;
CC P0CB47; Q01850: CDR2; NbExp=3; IntAct=EBI-17208936, EBI-1181367;
CC P0CB47; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-17208936, EBI-742054;
CC P0CB47; A1L4K1: FSD2; NbExp=3; IntAct=EBI-17208936, EBI-5661036;
CC P0CB47; Q08379: GOLGA2; NbExp=3; IntAct=EBI-17208936, EBI-618309;
CC P0CB47; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-17208936, EBI-5916454;
CC P0CB47; P52954: LBX1; NbExp=3; IntAct=EBI-17208936, EBI-20141748;
CC P0CB47; O95751: LDOC1; NbExp=3; IntAct=EBI-17208936, EBI-740738;
CC P0CB47; P50458: LHX2; NbExp=3; IntAct=EBI-17208936, EBI-12179869;
CC P0CB47; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-17208936, EBI-12039345;
CC P0CB47; Q9NQ69: LHX9; NbExp=3; IntAct=EBI-17208936, EBI-10175218;
CC P0CB47; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-17208936, EBI-11522433;
CC P0CB47; Q96RE7: NACC1; NbExp=3; IntAct=EBI-17208936, EBI-7950997;
CC P0CB47; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-17208936, EBI-17490746;
CC P0CB47; Q6IEY1: OR4F29; NbExp=3; IntAct=EBI-17208936, EBI-18294332;
CC P0CB47; Q8N127: OR5AS1; NbExp=3; IntAct=EBI-17208936, EBI-19949977;
CC P0CB47; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-17208936, EBI-10302990;
CC P0CB47; Q9UHX1-2: PUF60; NbExp=3; IntAct=EBI-17208936, EBI-11529177;
CC P0CB47; Q15276: RABEP1; NbExp=3; IntAct=EBI-17208936, EBI-447043;
CC P0CB47; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-17208936, EBI-11957366;
CC P0CB47; Q16623: STX1A; NbExp=3; IntAct=EBI-17208936, EBI-712466;
CC P0CB47; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-17208936, EBI-529518;
CC P0CB47; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-17208936, EBI-1105213;
CC P0CB47; O15156-2: ZBTB7B; NbExp=3; IntAct=EBI-17208936, EBI-11522250;
CC P0CB47; Q96NG5: ZNF558; NbExp=3; IntAct=EBI-17208936, EBI-373363;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3USZ2}. Nucleus
CC {ECO:0000250|UniProtKB:Q3USZ2, ECO:0000255|PROSITE-ProRule:PRU00267}.
CC Note=Mainly cytoplasmic from the 4-cell stage to the morula stage.
CC Becomes nuclear at the blastocyst stage.
CC {ECO:0000250|UniProtKB:Q3USZ2}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP000827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS44704.1; -.
DR RefSeq; NP_001137447.1; NM_001143975.1.
DR AlphaFoldDB; P0CB47; -.
DR SMR; P0CB47; -.
DR BioGRID; 568124; 30.
DR IntAct; P0CB47; 26.
DR STRING; 9606.ENSP00000485108; -.
DR iPTMnet; P0CB47; -.
DR PhosphoSitePlus; P0CB47; -.
DR BioMuta; UBTFL1; -.
DR DMDM; 263545802; -.
DR PeptideAtlas; P0CB47; -.
DR PRIDE; P0CB47; -.
DR ProteomicsDB; 52437; -.
DR Antibodypedia; 74795; 22 antibodies from 11 providers.
DR DNASU; 642623; -.
DR Ensembl; ENST00000530464.2; ENSP00000485108.1; ENSG00000255009.4.
DR GeneID; 642623; -.
DR KEGG; hsa:642623; -.
DR MANE-Select; ENST00000530464.2; ENSP00000485108.1; NM_001143975.1; NP_001137447.1.
DR UCSC; uc010rub.2; human.
DR CTD; 642623; -.
DR GeneCards; UBTFL1; -.
DR HGNC; HGNC:14533; UBTFL1.
DR HPA; ENSG00000255009; Not detected.
DR MIM; 613696; gene.
DR neXtProt; NX_P0CB47; -.
DR OpenTargets; ENSG00000255009; -.
DR PharmGKB; PA164727456; -.
DR VEuPathDB; HostDB:ENSG00000255009; -.
DR eggNOG; KOG0381; Eukaryota.
DR GeneTree; ENSGT00940000163858; -.
DR HOGENOM; CLU_021068_0_0_1; -.
DR InParanoid; P0CB47; -.
DR OMA; TAYIRFF; -.
DR OrthoDB; 1237679at2759; -.
DR PhylomeDB; P0CB47; -.
DR PathwayCommons; P0CB47; -.
DR SignaLink; P0CB47; -.
DR BioGRID-ORCS; 642623; 3 hits in 143 CRISPR screens.
DR GenomeRNAi; 642623; -.
DR Pharos; P0CB47; Tdark.
DR PRO; PR:P0CB47; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P0CB47; protein.
DR Bgee; ENSG00000255009; Expressed in hindlimb stylopod muscle and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001164; F:RNA polymerase I core promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001181; F:RNA polymerase I general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0001832; P:blastocyst growth; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0006360; P:transcription by RNA polymerase I; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; SSF47095; 2.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1..393
FT /note="Upstream-binding factor 1-like protein 1"
FT /id="PRO_0000386640"
FT DNA_BIND 100..168
FT /note="HMG box 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT DNA_BIND 222..288
FT /note="HMG box 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 308..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 46134 MW; 82B979D273A5ED63 CRC64;
MALPRSQGHW SNKDILRLLE CMENNRPSDD NSTFSSTQSH MDWGKVAFKN FSGEMCRLKW
LEISCNLRKF GTLKELVLEA KKCVKKMNKS QKYRNGPDFP KRPLTAYNRF FKESWPQYSQ
MYPGMRSQEL TKILSKKYRE LPEQMKQKYI QDFRKEKQEF EEKLARFREE HPDLVQKAKK
SSVSKRTQNK VQKKFQKNIE EVRSLPKTDR FFKKVKFHGE PQKPPMNGYH KFHQDSWSSK
EMQHLSVRER MVEIGRRWQR IPQSQKDHFK SQAEELQKQY KVKLDLWLKT LSPENYAAYK
ESTYAKGKNM AMTGGPDPRL KQADPQSSSA KGLQEGFGEG QGLQAAGTDS SQTIWVNCHV
SMEPEENRKK DREKEESSNS SDCSSGEEIE VDV
