UBIA1_CHICK
ID UBIA1_CHICK Reviewed; 333 AA.
AC Q5ZKS8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=UbiA prenyltransferase domain-containing protein 1;
DE EC=2.5.1.-;
GN Name=UBIAD1; ORFNames=RCJMB04_9f15;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Prenyltransferase that mediates the formation of menaquinone-
CC 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for
CC endothelial cell development. Mediates the conversion of phylloquinone
CC (PK) into MK-4, probably by cleaving the side chain of phylloquinone
CC (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then
CC prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4.
CC Also plays a role in cardiovascular development independently of MK-4
CC biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme
CC Q10, also named ubiquinone, plays an important antioxidant role in the
CC cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the
CC Golgi membrane, leading to protect cardiovascular tissues from
CC NOS3/eNOS-dependent oxidative stress (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC {ECO:0000305}.
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DR EMBL; AJ720006; CAG31665.1; -; mRNA.
DR RefSeq; NP_001026050.1; NM_001030879.1.
DR AlphaFoldDB; Q5ZKS8; -.
DR STRING; 9031.ENSGALP00000005301; -.
DR PaxDb; Q5ZKS8; -.
DR GeneID; 419456; -.
DR KEGG; gga:419456; -.
DR CTD; 29914; -.
DR VEuPathDB; HostDB:geneid_419456; -.
DR eggNOG; KOG4581; Eukaryota.
DR InParanoid; Q5ZKS8; -.
DR OrthoDB; 1146311at2759; -.
DR PhylomeDB; Q5ZKS8; -.
DR UniPathway; UPA00079; -.
DR UniPathway; UPA00232; -.
DR PRO; PR:Q5ZKS8; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030173; C:integral component of Golgi membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0016209; F:antioxidant activity; ISS:UniProtKB.
DR GO; GO:0004659; F:prenyltransferase activity; ISS:UniProtKB.
DR GO; GO:0072359; P:circulatory system development; ISS:UniProtKB.
DR GO; GO:0001885; P:endothelial cell development; ISS:UniProtKB.
DR GO; GO:0009234; P:menaquinone biosynthetic process; ISS:UniProtKB.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:UniProtKB.
DR GO; GO:0032194; P:ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; IBA:GO_Central.
DR GO; GO:0042371; P:vitamin K biosynthetic process; ISS:UniProtKB.
DR CDD; cd13962; PT_UbiA_UBIAD1; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR044878; UbiA_sf.
DR InterPro; IPR026046; UBIAD1.
DR PANTHER; PTHR13929; PTHR13929; 1.
DR Pfam; PF01040; UbiA; 1.
DR PIRSF; PIRSF005355; UBIAD1; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Menaquinone biosynthesis;
KW Mitochondrion; Prenyltransferase; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix; Ubiquinone biosynthesis.
FT CHAIN 1..333
FT /note="UbiA prenyltransferase domain-containing protein 1"
FT /id="PRO_0000242629"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 13..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 333 AA; 35750 MW; CA5ED4730688D86E CRC64;
MGPAELVQKI SINAESPRGG ERNDCGAGAE RGPAGGWRQK CAAYVLALRP WSFSASLTPV
ALGSALAYRA EGALDPRLLV GSAVAVLAVH GAGNLVNTYY DFSKGIDHKK SDDRTLVDQI
LEPQDVVRFG VFLYTVGCIC AAGLYAVSTL KLEHLALVYF GGLSSSFLYT GGIGFKYVAL
GDVVILITFG PLAVMFAHAV QVGYLSVSPL LYAVPLALST EAILHSNNTR DMESDQQAGI
VTLAIIIGPA FSYVLYTVLL FLPYLIFCVL ATRYTISMAL PLLTIPMAFS LERQFRSQNF
NKIPQRTAKL NLLLGLFYVF GIMLAPAGAL PKL
