ID   UBIA1_DICDI             Reviewed;         330 AA.
AC   Q54K99;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=UbiA prenyltransferase domain-containing protein 1;
GN   Name=ubiad1; ORFNames=DDB_G0287509;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Prenyltransferase that mediates the formation of menaquinone-
CC       4 (MK-4), a vitamin K2 isoform. {ECO:0000250}.
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000102; EAL63654.1; -; Genomic_DNA.
DR   RefSeq; XP_637156.1; XM_632064.1.
DR   AlphaFoldDB; Q54K99; -.
DR   SMR; Q54K99; -.
DR   STRING; 44689.DDB0231539; -.
DR   PaxDb; Q54K99; -.
DR   EnsemblProtists; EAL63654; EAL63654; DDB_G0287509.
DR   GeneID; 8626157; -.
DR   KEGG; ddi:DDB_G0287509; -.
DR   dictyBase; DDB_G0287509; -.
DR   eggNOG; KOG4581; Eukaryota.
DR   HOGENOM; CLU_043611_0_0_1; -.
DR   InParanoid; Q54K99; -.
DR   OMA; QWIEGAR; -.
DR   PhylomeDB; Q54K99; -.
DR   Reactome; R-DDI-6806664; Metabolism of vitamin K.
DR   UniPathway; UPA00079; -.
DR   PRO; PR:Q54K99; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004659; F:prenyltransferase activity; IBA:GO_Central.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IBA:GO_Central.
DR   GO; GO:0032194; P:ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; IBA:GO_Central.
DR   GO; GO:0042371; P:vitamin K biosynthetic process; IBA:GO_Central.
DR   CDD; cd13962; PT_UbiA_UBIAD1; 1.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR026046; UBIAD1.
DR   PANTHER; PTHR13929; PTHR13929; 1.
DR   Pfam; PF01040; UbiA; 1.
DR   PIRSF; PIRSF005355; UBIAD1; 1.
PE   3: Inferred from homology;
KW   Membrane; Menaquinone biosynthesis; Prenyltransferase; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="UbiA prenyltransferase domain-containing protein 1"
FT                   /id="PRO_0000327579"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   330 AA;  36794 MW;  B139146B06371516 CRC64;
     MSTTINRNEK TKQVVNKTKE IKTESSQQQQ QKPPISKLMG IILATRPWSL TISVTSVLVG
     SALAFREIRE FDSIMLSIIL VGAVSLQALG NVVNSFYDCK NGNDTKEKSA DRTMFDFGLT
     EGNIINLIWY LLIQCAICLG LMIFRMDNIK CIVENILPLG AFGFILNISY TAAPIGLKYI
     GLGDLTIFLC FGPILVQSAF ISQTHYHDSL AYFYSIPLAL TIVAVLHVNN TRDIKADTEA
     GSITLASKLG FKNCYYIYAG LYLFAYIYLF KLSLDIDKYI LNLPLILIPK IISLINQFKN
     KKLEDLTEKT GQLSFFFGGL NAIGVLLSMQ