UBIA1_XENTR
ID UBIA1_XENTR Reviewed; 345 AA.
AC Q28HR4; B3DLT5; B7ZSP1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=UbiA prenyltransferase domain-containing protein 1;
DE EC=2.5.1.-;
GN Name=ubiad1; ORFNames=TTpA003i03.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Neurula;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Prenyltransferase that mediates the formation of menaquinone-
CC 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for
CC endothelial cell development. Mediates the conversion of phylloquinone
CC (PK) into MK-4, probably by cleaving the side chain of phylloquinone
CC (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then
CC prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4.
CC Also plays a role in cardiovascular development independently of MK-4
CC biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme
CC Q10, also named ubiquinone, plays an important antioxidant role in the
CC cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the
CC Golgi membrane, leading to protect cardiovascular tissues from
CC nos3/eNOS-dependent oxidative stress (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC {ECO:0000305}.
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DR EMBL; CR760773; CAJ82974.1; -; mRNA.
DR EMBL; BC167573; AAI67573.1; -; mRNA.
DR EMBL; BC170591; AAI70591.1; -; mRNA.
DR EMBL; BC170593; AAI70593.1; -; mRNA.
DR RefSeq; NP_001016538.1; NM_001016538.2.
DR RefSeq; XP_012822063.1; XM_012966609.1.
DR RefSeq; XP_017950881.1; XM_018095392.1.
DR AlphaFoldDB; Q28HR4; -.
DR SMR; Q28HR4; -.
DR GeneID; 549292; -.
DR KEGG; xtr:549292; -.
DR CTD; 29914; -.
DR Xenbase; XB-GENE-963273; ubiad1.
DR InParanoid; Q28HR4; -.
DR OrthoDB; 1146311at2759; -.
DR Reactome; R-XTR-6806664; Metabolism of vitamin K.
DR UniPathway; UPA00079; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030173; C:integral component of Golgi membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0016209; F:antioxidant activity; ISS:UniProtKB.
DR GO; GO:0004659; F:prenyltransferase activity; ISS:UniProtKB.
DR GO; GO:0072359; P:circulatory system development; ISS:UniProtKB.
DR GO; GO:0001885; P:endothelial cell development; ISS:UniProtKB.
DR GO; GO:0009234; P:menaquinone biosynthetic process; ISS:UniProtKB.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:UniProtKB.
DR GO; GO:0032194; P:ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; IBA:GO_Central.
DR GO; GO:0042371; P:vitamin K biosynthetic process; ISS:UniProtKB.
DR CDD; cd13962; PT_UbiA_UBIAD1; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR044878; UbiA_sf.
DR InterPro; IPR026046; UBIAD1.
DR PANTHER; PTHR13929; PTHR13929; 1.
DR Pfam; PF01040; UbiA; 1.
DR PIRSF; PIRSF005355; UBIAD1; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Menaquinone biosynthesis;
KW Mitochondrion; Prenyltransferase; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix; Ubiquinone biosynthesis.
FT CHAIN 1..345
FT /note="UbiA prenyltransferase domain-containing protein 1"
FT /id="PRO_0000242630"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 85
FT /note="G -> E (in Ref. 2; AAI67573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 37808 MW; 8685C9BD9F81A758 CRC64;
MKPDDCLNNI HIETENLDEV DLTKLTGEAH SLSNGIVPPF TDKTFRKATS FKQKCATYVL
ALRPWSFSAS LIPVALGTAI AYRSGGSLDL LLFVVCAVAV LAVHGAGNLV NTYYDFSKGI
DHKKSDDRTL VDHILEPQDV VRFGVFLYTL GCLCAACLYF ISKLKLEHLA LIYFGGLSSS
FLYTGGIGFK YVALGDLVIL ITFGPLAVMF AHAVQVGYLA VTPLLYAVPL ALSTEAILHS
NNTRDMESDR QAGIVTLAIL VGPMFSYMLY NLLVFLPYLI FSILATRYTI SMALPLLTIP
LAFSLERQFR SQNFNKIPQR TAKLNLLVGL FYVFGIVLAP AGSLP
