ID   C7_CAMPM                Reviewed;         150 AA.
AC   P68643; Q8V2Z8;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   12-AUG-2020, entry version 28.
DE   RecName: Full=Probable host range protein 2;
GN   OrderedLocusNames=CMLV019;
OS   Camelpox virus (strain M-96).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=203173;
OH   NCBI_TaxID=9836; Camelus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12033760; DOI=10.1006/viro.2001.1343;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Sandybaev N.T., Kerembekova U.Z.,
RA   Zaitsev V.L., Kutish G.F., Rock D.L.;
RT   "The genome of camelpox virus.";
RL   Virology 295:1-9(2002).
CC   -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC       Does not block signal transduction of IFN, but is important to
CC       counteract the host antiviral state induced by a pre-treatment with IFN
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
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DR   EMBL; AF438165; AAL73726.1; -; Genomic_DNA.
DR   RefSeq; NP_570409.1; NC_003391.1.
DR   SMR; P68643; -.
DR   GeneID; 932681; -.
DR   KEGG; vg:932681; -.
DR   Proteomes; UP000152221; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR004967; Poxvirus_C7/F8A.
DR   Pfam; PF03287; Pox_C7_F8A; 1.
DR   PIRSF; PIRSF003779; VAC_C7L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Viral immunoevasion.
FT   CHAIN           1..150
FT                   /note="Probable host range protein 2"
FT                   /id="PRO_0000099390"
SQ   SEQUENCE   150 AA;  18069 MW;  3D5557A68AF83D95 CRC64;
     MGIQHEFDII INGDIALRNL QLHRGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG
     LTVFANNYVV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDEKELFKH YYPYISLNMI
     SKKYKVKEEN YSSPYIEHPL IPYRDYESMD