ID   C7_CAMPS                Reviewed;         150 AA.
AC   P68642; Q8V2Z8;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Probable host range protein 2;
GN   OrderedLocusNames=CMP19L;
OS   Camelpox virus (strain CMS).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=203172;
OH   NCBI_TaxID=9836; Camelus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11907336; DOI=10.1099/0022-1317-83-4-855;
RA   Gubser C., Smith G.L.;
RT   "The sequence of camelpox virus shows it is most closely related to variola
RT   virus, the cause of smallpox.";
RL   J. Gen. Virol. 83:855-872(2002).
CC   -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC       Does not block signal transduction of IFN, but is important to
CC       counteract the host antiviral state induced by a pre-treatment with IFN
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
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DR   EMBL; AY009089; AAG37475.1; -; Genomic_DNA.
DR   SMR; P68642; -.
DR   Proteomes; UP000107153; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR004967; Poxvirus_C7/F8A.
DR   Pfam; PF03287; Pox_C7_F8A; 1.
DR   PIRSF; PIRSF003779; VAC_C7L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Viral immunoevasion.
FT   CHAIN           1..150
FT                   /note="Probable host range protein 2"
FT                   /id="PRO_0000099391"
SQ   SEQUENCE   150 AA;  18069 MW;  3D5557A68AF83D95 CRC64;
     MGIQHEFDII INGDIALRNL QLHRGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG
     LTVFANNYVV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDEKELFKH YYPYISLNMI
     SKKYKVKEEN YSSPYIEHPL IPYRDYESMD