C7_VACCA
ID C7_VACCA Reviewed; 150 AA.
AC P68598; P17363; Q76ZY7;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 02-JUN-2021, entry version 39.
DE RecName: Full=Interferon antagonist C7;
DE AltName: Full=Host range protein 2;
GN OrderedLocusNames=MVA018L, ACAM3000_MVA_018; ORFNames=C7L;
OS Vaccinia virus (strain Ankara) (VACV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=126794;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT "The complete genomic sequence of the modified vaccinia Ankara strain:
RT comparison with other orthopoxviruses.";
RL Virology 244:365-396(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Acambis 3000;
RA Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA Khristova M., Wohlhueter R.M.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC Does not block signal transduction of IFN, but is important to
CC counteract the host antiviral state induced by a pre-treatment with IFN
CC (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
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DR EMBL; U94848; AAB96405.1; -; Genomic_DNA.
DR EMBL; AY603355; AAT10416.1; -; Genomic_DNA.
DR PIR; A33348; WZVZB1.
DR RefSeq; YP_232903.1; NC_006998.1.
DR PDB; 5CYW; X-ray; 2.00 A; B=1-150.
DR PDBsum; 5CYW; -.
DR SMR; P68598; -.
DR DNASU; 3707636; -.
DR GeneID; 3707636; -.
DR KEGG; vg:3707636; -.
DR Proteomes; UP000159908; Genome.
DR Proteomes; UP000172909; Genome.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR004967; Poxvirus_C7/F8A.
DR Pfam; PF03287; Pox_C7_F8A; 1.
DR PIRSF; PIRSF003779; VAC_C7L; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Early protein; Host-virus interaction;
KW Inhibition of host innate immune response by virus; Viral immunoevasion.
FT CHAIN 1..150
FT /note="Interferon antagonist C7"
FT /id="PRO_0000099386"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:5CYW"
FT TURN 12..14
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 15..18
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 23..26
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 29..35
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 40..49
FT /evidence="ECO:0007829|PDB:5CYW"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 62..65
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 73..77
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 82..89
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 92..101
FT /evidence="ECO:0007829|PDB:5CYW"
FT HELIX 107..110
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 114..118
FT /evidence="ECO:0007829|PDB:5CYW"
FT TURN 119..122
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 123..128
FT /evidence="ECO:0007829|PDB:5CYW"
FT STRAND 135..139
FT /evidence="ECO:0007829|PDB:5CYW"
FT HELIX 145..147
FT /evidence="ECO:0007829|PDB:5CYW"
SQ SEQUENCE 150 AA; 17999 MW; 47CDF841D563C0A4 CRC64;
MGIQHEFDII INGDIALRNL QLHKGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG
LTVFANNYAV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDENELFKH YYPYISLNMI
SKKYKVKEEN YSSPYIEHPL IPYRDYESMD
