ID   C7_VACCC                Reviewed;         150 AA.
AC   P68599; P17363;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   29-SEP-2021, entry version 38.
DE   RecName: Full=Interferon antagonist C7;
DE   AltName: Full=Host range protein 2;
GN   ORFNames=C7L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC       Does not block signal transduction of IFN, but is important to
CC       counteract the host antiviral state induced by a pre-treatment with IFN
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
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DR   EMBL; M35027; AAA47993.1; -; Genomic_DNA.
DR   PIR; A33348; WZVZB1.
DR   SMR; P68599; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR004967; Poxvirus_C7/F8A.
DR   Pfam; PF03287; Pox_C7_F8A; 1.
DR   PIRSF; PIRSF003779; VAC_C7L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..150
FT                   /note="Interferon antagonist C7"
FT                   /id="PRO_0000099387"
SQ   SEQUENCE   150 AA;  17999 MW;  47CDF841D563C0A4 CRC64;
     MGIQHEFDII INGDIALRNL QLHKGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG
     LTVFANNYAV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDENELFKH YYPYISLNMI
     SKKYKVKEEN YSSPYIEHPL IPYRDYESMD