ID   C7_VACCW                Reviewed;         150 AA.
AC   P68600; P17363; Q76ZY7;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   02-JUN-2021, entry version 44.
DE   RecName: Full=Interferon antagonist C7;
DE   AltName: Full=Host range protein 2;
GN   OrderedLocusNames=VACWR021; ORFNames=C7L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2849238; DOI=10.1016/s0042-6822(88)90115-8;
RA   Kotwal G.J., Moss B.;
RT   "Analysis of a large cluster of nonessential genes deleted from a vaccinia
RT   virus terminal transposition mutant.";
RL   Virology 167:524-537(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=2171207; DOI=10.1016/0042-6822(90)90296-4;
RA   Perkus M.E., Goebel S.J., Davis S.W., Johnson G.P., Limbach K.,
RA   Norton E.K., Paoletti E.;
RT   "Vaccinia virus host range genes.";
RL   Virology 179:276-286(1990).
RN   [4]
RP   FUNCTION.
RX   PubMed=8336123; DOI=10.1099/0022-1317-74-7-1409;
RA   Oguiura N., Spehner D., Drillien R.;
RT   "Detection of a protein encoded by the vaccinia virus C7L open reading
RT   frame and study of its effect on virus multiplication in different cell
RT   lines.";
RL   J. Gen. Virol. 74:1409-1413(1993).
RN   [5]
RP   FUNCTION.
RX   PubMed=19656868; DOI=10.1128/jvi.01260-09;
RA   Meng X., Jiang C., Arsenio J., Dick K., Cao J., Xiang Y.;
RT   "Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I
RT   interferons.";
RL   J. Virol. 83:10627-10636(2009).
CC   -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC       Does not block signal transduction of IFN, but is important to
CC       counteract the host antiviral state induced by a pre-treatment with
CC       IFN. {ECO:0000269|PubMed:19656868, ECO:0000269|PubMed:2171207,
CC       ECO:0000269|PubMed:8336123}.
CC   -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
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DR   EMBL; M22812; AAA69601.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89300.1; -; Genomic_DNA.
DR   PIR; A33348; WZVZB1.
DR   RefSeq; YP_232903.1; NC_006998.1.
DR   SMR; P68600; -.
DR   DNASU; 3707636; -.
DR   GeneID; 3707636; -.
DR   KEGG; vg:3707636; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR004967; Poxvirus_C7/F8A.
DR   Pfam; PF03287; Pox_C7_F8A; 1.
DR   PIRSF; PIRSF003779; VAC_C7L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..150
FT                   /note="Interferon antagonist C7"
FT                   /id="PRO_0000099388"
SQ   SEQUENCE   150 AA;  17999 MW;  47CDF841D563C0A4 CRC64;
     MGIQHEFDII INGDIALRNL QLHKGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG
     LTVFANNYAV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDENELFKH YYPYISLNMI
     SKKYKVKEEN YSSPYIEHPL IPYRDYESMD