ID   C7_VAR67                Reviewed;         150 AA.
AC   P0DSW7; P33860;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   12-AUG-2020, entry version 5.
DE   RecName: Full=truncated interferon antagonist D8;
DE   AltName: Full=Host range protein 2;
GN   ORFNames=D8L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC       Does not block signal transduction of IFN, but is important to
CC       counteract the host antiviral state induced by a pre-treatment with IFN
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
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DR   EMBL; X69198; CAA48949.1; -; Genomic_DNA.
DR   PIR; H36837; H36837.
DR   RefSeq; NP_042052.1; NC_001611.1.
DR   SMR; P0DSW7; -.
DR   GeneID; 1486403; -.
DR   KEGG; vg:1486403; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR004967; Poxvirus_C7/F8A.
DR   Pfam; PF03287; Pox_C7_F8A; 1.
DR   PIRSF; PIRSF003779; VAC_C7L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..150
FT                   /note="truncated interferon antagonist D8"
FT                   /id="PRO_0000099389"
SQ   SEQUENCE   150 AA;  18027 MW;  50FDF841C253CE94 CRC64;
     MGIQHEFDII INGDIALRNL QLHRGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG
     LTVFANNYAV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDENELFKH YYPYISLNMI
     SKKYKVKEEN YSSPYIEHPL IPYRDYESMD