ID   C7_VARV                 Reviewed;         150 AA.
AC   P0DSW8; P33860;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=truncated interferon antagonist D8;
DE   AltName: Full=Host range protein 2;
GN   ORFNames=D8L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Congo-1965, Garcia-1966, and Somalia-1977;
RA   Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M.,
RA   Totmenin A.V., Shchelkunov S.N., Esposito J.J.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC       Does not block signal transduction of IFN, but is important to
CC       counteract the host antiviral state induced by a pre-treatment with IFN
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae C7 protein family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60756.1; -; Genomic_DNA.
DR   EMBL; U18340; AAA69419.1; -; Genomic_DNA.
DR   EMBL; U18337; AAA69313.1; -; Genomic_DNA.
DR   EMBL; U18338; AAA69354.1; -; Genomic_DNA.
DR   PIR; F72151; F72151.
DR   PIR; T28446; T28446.
DR   RefSeq; NP_042052.1; NC_001611.1.
DR   SMR; P0DSW8; -.
DR   GeneID; 1486403; -.
DR   KEGG; vg:1486403; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR004967; Poxvirus_C7/F8A.
DR   Pfam; PF03287; Pox_C7_F8A; 1.
DR   PIRSF; PIRSF003779; VAC_C7L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Viral immunoevasion.
FT   CHAIN           1..150
FT                   /note="truncated interferon antagonist D8"
FT                   /id="PRO_0000448175"
SQ   SEQUENCE   150 AA;  18027 MW;  50FDF841C253CE94 CRC64;
     MGIQHEFDII INGDIALRNL QLHRGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG
     LTVFANNYAV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDENELFKH YYPYISLNMI
     SKKYKVKEEN YSSPYIEHPL IPYRDYESMD