ID   UBIB_PSEAE              Reviewed;         533 AA.
AC   Q9HUB8;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable protein kinase UbiB {ECO:0000255|HAMAP-Rule:MF_00414};
DE            EC=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_00414};
DE   AltName: Full=Ubiquinone biosynthesis protein UbiB {ECO:0000255|HAMAP-Rule:MF_00414};
GN   Name=ubiB {ECO:0000255|HAMAP-Rule:MF_00414}; OrderedLocusNames=PA5065;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Is probably a protein kinase regulator of UbiI activity which
CC       is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00414}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis [regulation].
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00414}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00414}.
CC   -!- SIMILARITY: Belongs to the ABC1 family. UbiB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00414}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; AAG08450.1; -; Genomic_DNA.
DR   PIR; D83014; D83014.
DR   RefSeq; NP_253752.1; NC_002516.2.
DR   RefSeq; WP_003095885.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; Q9HUB8; -.
DR   SMR; Q9HUB8; -.
DR   STRING; 287.DR97_2420; -.
DR   PaxDb; Q9HUB8; -.
DR   PRIDE; Q9HUB8; -.
DR   EnsemblBacteria; AAG08450; AAG08450; PA5065.
DR   GeneID; 878018; -.
DR   KEGG; pae:PA5065; -.
DR   PATRIC; fig|208964.12.peg.5309; -.
DR   PseudoCAP; PA5065; -.
DR   HOGENOM; CLU_006533_0_0_6; -.
DR   InParanoid; Q9HUB8; -.
DR   OMA; RRDYKRV; -.
DR   PhylomeDB; Q9HUB8; -.
DR   BioCyc; PAER208964:G1FZ6-5181-MON; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0010795; P:regulation of ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd13972; UbiB; 1.
DR   HAMAP; MF_00414; UbiB; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR010232; UbiB.
DR   InterPro; IPR045308; UbiB_bact.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR01982; UbiB; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Kinase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix; Ubiquinone biosynthesis.
FT   CHAIN           1..533
FT                   /note="Probable protein kinase UbiB"
FT                   /id="PRO_0000200714"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00414"
FT   TRANSMEM        510..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00414"
FT   DOMAIN          126..494
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00414"
FT   ACT_SITE        289
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00414"
FT   BINDING         132..140
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00414"
FT   BINDING         154
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00414"
SQ   SEQUENCE   533 AA;  61722 MW;  E30490993C144862 CRC64;
     MKLLAVRRLL RIQRVVIRYR LDDLILELPM LPWWLRLLGA TLPWRWLPRR KLELTRGARL
     RLALQDLGPI FIKFGQILST RRDLLPDDIA NELAWLQDKV PPFPPELAVK RIEEQLGAKI
     EQVFARFERE PLASASVAQV HAARLKSGEE VVVKVIRPNL EPVIRSDIAW LFILARLAER
     VSSEARRLHP VEVVSDYEKT IVDELDLLRE AANASQLRRN FEGSPLLYVP QVYWDWCRPK
     VLVMERIYGI PVTDLETLRD QRTDFKALAE RGVEIFFTQV FRDSFFHADM HPGNIFVSTR
     APWSPQYIAV DCGIVGSLTD EDQDYLARNL IAFFKRDYRK VAQLHIDSGW VPAETKVNDF
     EAAIRTVCEP IFEKPLKDIS FGQVLLRLFQ TARRFNMEIQ PQLVLLQKTL LNIEGLGRQL
     YPELDLWATA QPFLERWMRE RVSPKQLLRN FQQQVEQVPH LSQMARDTLE RLSQPHAHNA
     PPPEWKGSRH DWLGRLVGAV LLVGAAEVGL GQQLEAWPAW VMLAGGVFLI LRR