C85A1_ARATH
ID C85A1_ARATH Reviewed; 465 AA.
AC Q9FMA5;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Cytochrome P450 85A1 {ECO:0000303|PubMed:12427998};
DE Short=AtCYP85A1 {ECO:0000303|PubMed:12427998};
DE EC=1.14.-.- {ECO:0000269|PubMed:11402205};
DE AltName: Full=3-dehydroteasterone synthase {ECO:0000303|PubMed:11402205};
DE EC=1.14.14.- {ECO:0000269|PubMed:11402205};
DE AltName: Full=Brassinosteroid-6-oxidase 1 {ECO:0000303|PubMed:12529536};
DE Short=BR6ox 1 {ECO:0000303|PubMed:12529536};
DE AltName: Full=C6-oxidase 1 {ECO:0000303|PubMed:12529536};
DE AltName: Full=Castasterone synthase {ECO:0000303|PubMed:11402205};
DE EC=1.14.14.- {ECO:0000269|PubMed:11402205};
DE AltName: Full=Teasterone synthase {ECO:0000303|PubMed:11402205};
DE EC=1.14.14.- {ECO:0000269|PubMed:11402205};
DE AltName: Full=Typhasterol synthase {ECO:0000303|PubMed:11402205};
DE EC=1.14.14.- {ECO:0000269|PubMed:11402205};
GN Name=CYP85A1 {ECO:0000303|PubMed:12427998};
GN Synonyms=BR6OX1 {ECO:0000303|PubMed:12529536};
GN OrderedLocusNames=At5g38970 {ECO:0000312|Araport:AT5G38970};
GN ORFNames=K15E6.150 {ECO:0000312|EMBL:BAB08653.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, AND
RP PATHWAY.
RX PubMed=11402205; DOI=10.1104/pp.126.2.770;
RA Shimada Y., Fujioka S., Miyauchi N., Kushiro M., Takatsuto S., Nomura T.,
RA Yokota T., Kamiya Y., Bishop G.J., Yoshida S.;
RT "Brassinosteroid-6-oxidases from Arabidopsis and tomato catalyze multiple
RT C-6 oxidations in brassinosteroid biosynthesis.";
RL Plant Physiol. 126:770-779(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP INDUCTION.
RX PubMed=12427998; DOI=10.1104/pp.011254;
RA Goda H., Shimada Y., Asami T., Fujioka S., Yoshida S.;
RT "Microarray analysis of brassinosteroid-regulated genes in Arabidopsis.";
RL Plant Physiol. 130:1319-1334(2002).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12529536; DOI=10.1104/pp.013029;
RA Shimada Y., Goda H., Nakamura A., Takatsuto S., Fujioka S., Yoshida S.;
RT "Organ-specific expression of brassinosteroid-biosynthetic genes and
RT distribution of endogenous brassinosteroids in Arabidopsis.";
RL Plant Physiol. 131:287-297(2003).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=21364326; DOI=10.4161/psb.6.3.13206;
RA Perez-Espana V.H., Sanchez-Leon N., Vielle-Calzada J.-P.;
RT "CYP85A1 is required for the initiation of female gametogenesis in
RT Arabidopsis thaliana.";
RL Plant Signal. Behav. 6:321-326(2011).
RN [7]
RP TISSUE SPECIFICITY, AND INDUCTION BY LIGHT.
RX PubMed=32333772; DOI=10.1093/pcp/pcaa053;
RA Hamasaki H., Ayano M., Nakamura A., Fujioka S., Asami T., Takatsuto S.,
RA Yoshida S., Oka Y., Matsui M., Shimada Y.;
RT "Light activates brassinosteroid biosynthesis to promote hook opening and
RT petiole development in Arabidopsis thaliana.";
RL Plant Cell Physiol. 61:1239-1251(2020).
CC -!- FUNCTION: Catalyzes the C6-oxidation step in brassinosteroids
CC biosynthesis (PubMed:11402205, PubMed:12529536). Converts 6-
CC deoxocastasterone (6-deoxoCS) to castasterone (CS). May also convert 6-
CC deoxoteasterone (6-deoxoTE) to teasterone (TE), 3-dehydro-6-
CC deoxoteasterone (6-deoxo3DT, 6-deoxo-3-DHT) to 3-dehydroteasterone
CC (3DT, 3-DHT), and 6-deoxotyphasterol (6-deoxoTY) to typhasterol (TY)
CC (PubMed:11402205, PubMed:12529536). Required for the initiation of
CC female gametogenesis (megagametogenesis) (PubMed:21364326).
CC {ECO:0000269|PubMed:11402205, ECO:0000269|PubMed:12529536,
CC ECO:0000269|PubMed:21364326}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein
CC reductase] = 6alpha-hydroxyteasterone + H(+) + H2O + oxidized
CC [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:69959, Rhea:RHEA-
CC COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:20716,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:188499;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69960;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein
CC reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] +
CC teasterone; Xref=Rhea:RHEA:69963, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:26863, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC ChEBI:CHEBI:188495; Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69964;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein
CC reductase] = 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O +
CC oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:69947,
CC Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:20710,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:188496;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69948;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--
CC hemoprotein reductase] = 3-dehydroteasterone + H(+) + 2 H2O +
CC oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:69951,
CC Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:20000,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:188496;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69952;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein
CC reductase] = 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized
CC [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:69939, Rhea:RHEA-
CC COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:20717,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:188495;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69940;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein
CC reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] +
CC typhasterol; Xref=Rhea:RHEA:69943, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:27173, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC ChEBI:CHEBI:188495; Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69944;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein
CC reductase] = 6alpha-hydroxycastasterone + H(+) + H2O + oxidized
CC [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:69875, Rhea:RHEA-
CC COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:20712,
CC ChEBI:CHEBI:20760, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69876;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein
CC reductase] = castasterone + H(+) + 2 H2O + oxidized [NADPH--
CC hemoprotein reductase]; Xref=Rhea:RHEA:69879, Rhea:RHEA-COMP:11964,
CC Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:20760, ChEBI:CHEBI:23051,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69880;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--
CC hemoprotein reductase] = 3-dehydroteasterone + 2 H(+) + 3 H2O + 2
CC oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:70039,
CC Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:20000,
CC ChEBI:CHEBI:20710, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70040;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein
CC reductase] = castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--
CC hemoprotein reductase]; Xref=Rhea:RHEA:70031, Rhea:RHEA-COMP:11964,
CC Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:20712, ChEBI:CHEBI:23051,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70032;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein
CC reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein
CC reductase] + teasterone; Xref=Rhea:RHEA:70043, Rhea:RHEA-COMP:11964,
CC Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:20716, ChEBI:CHEBI:26863,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70044;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein
CC reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein
CC reductase] + typhasterol; Xref=Rhea:RHEA:70035, Rhea:RHEA-COMP:11964,
CC Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:20717, ChEBI:CHEBI:27173,
CC ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
CC Evidence={ECO:0000269|PubMed:11402205};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70036;
CC Evidence={ECO:0000269|PubMed:11402205};
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000250|UniProtKB:P04798};
CC -!- PATHWAY: Plant hormone biosynthesis; brassinosteroid biosynthesis.
CC {ECO:0000269|PubMed:11402205}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9FMA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FMA5-2; Sequence=VSP_014451;
CC Name=3;
CC IsoId=Q9FMA5-3; Sequence=VSP_014452, VSP_014453;
CC -!- TISSUE SPECIFICITY: Mainly expressed in apical shoots, hypocotyls,
CC siliques and roots (PubMed:12529536, PubMed:32333772). Also present in
CC the female gametophyte (PubMed:21364326). {ECO:0000269|PubMed:12529536,
CC ECO:0000269|PubMed:21364326, ECO:0000269|PubMed:32333772}.
CC -!- DEVELOPMENTAL STAGE: In the female gametophyte, accumulates in ovules
CC and its neighboring sporophytic cells. {ECO:0000269|PubMed:21364326}.
CC -!- INDUCTION: Repressed by brassinolide (BL) treatment (PubMed:12427998).
CC Induced rapidly and transiently in seedlings hooks but fades out of
CC hypocotyls after exposure to light (PubMed:32333772).
CC {ECO:0000269|PubMed:12427998, ECO:0000269|PubMed:32333772}.
CC -!- DISRUPTION PHENOTYPE: No obvious morphological alteration during
CC vegetative or floral development, but semi-sterile phenotype with
CC several female gametophytes arrested before the first nuclear mitotic
CC division of the haploid functional megaspore.
CC {ECO:0000269|PubMed:21364326}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AB035868; BAB60858.1; -; mRNA.
DR EMBL; AB009048; BAB08653.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94380.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94381.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94382.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70769.1; -; Genomic_DNA.
DR RefSeq; NP_001332353.1; NM_001344281.1. [Q9FMA5-2]
DR RefSeq; NP_198713.3; NM_123259.4. [Q9FMA5-2]
DR RefSeq; NP_851105.1; NM_180774.2. [Q9FMA5-1]
DR RefSeq; NP_974862.1; NM_203133.2. [Q9FMA5-3]
DR AlphaFoldDB; Q9FMA5; -.
DR SMR; Q9FMA5; -.
DR BioGRID; 19140; 15.
DR IntAct; Q9FMA5; 14.
DR STRING; 3702.AT5G38970.1; -.
DR PaxDb; Q9FMA5; -.
DR PRIDE; Q9FMA5; -.
DR EnsemblPlants; AT5G38970.1; AT5G38970.1; AT5G38970. [Q9FMA5-1]
DR EnsemblPlants; AT5G38970.2; AT5G38970.2; AT5G38970. [Q9FMA5-2]
DR EnsemblPlants; AT5G38970.3; AT5G38970.3; AT5G38970. [Q9FMA5-3]
DR EnsemblPlants; AT5G38970.4; AT5G38970.4; AT5G38970. [Q9FMA5-2]
DR GeneID; 833889; -.
DR Gramene; AT5G38970.1; AT5G38970.1; AT5G38970. [Q9FMA5-1]
DR Gramene; AT5G38970.2; AT5G38970.2; AT5G38970. [Q9FMA5-2]
DR Gramene; AT5G38970.3; AT5G38970.3; AT5G38970. [Q9FMA5-3]
DR Gramene; AT5G38970.4; AT5G38970.4; AT5G38970. [Q9FMA5-2]
DR KEGG; ath:AT5G38970; -.
DR Araport; AT5G38970; -.
DR TAIR; locus:2152292; AT5G38970.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_15_5_1; -.
DR InParanoid; Q9FMA5; -.
DR OMA; WTATRDR; -.
DR OrthoDB; 574756at2759; -.
DR PhylomeDB; Q9FMA5; -.
DR BioCyc; ARA:AT5G38970-MON; -.
DR BioCyc; MetaCyc:AT5G38970-MON; -.
DR UniPathway; UPA00381; -.
DR PRO; PR:Q9FMA5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FMA5; baseline and differential.
DR Genevisible; Q9FMA5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IDA:TAIR.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0016132; P:brassinosteroid biosynthetic process; IDA:TAIR.
DR GO; GO:0010268; P:brassinosteroid homeostasis; IEP:TAIR.
DR GO; GO:0009561; P:megagametogenesis; IMP:UniProtKB.
DR GO; GO:0009416; P:response to light stimulus; IEP:UniProtKB.
DR GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00465; EP450IV.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Brassinosteroid biosynthesis; Heme; Iron;
KW Lipid biosynthesis; Lipid metabolism; Membrane; Metal-binding;
KW Monooxygenase; Oxidoreductase; Reference proteome; Steroid biosynthesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..465
FT /note="Cytochrome P450 85A1"
FT /id="PRO_0000052169"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 415
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250|UniProtKB:P04798"
FT VAR_SEQ 1..81
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_014451"
FT VAR_SEQ 396..419
FT /note="KKSLESQNSCFVFGGGTRLCPGKE -> VSPWSHKTHALCLEVGQGFVLVRN
FT (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_014452"
FT VAR_SEQ 420..465
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_014453"
SQ SEQUENCE 465 AA; 53767 MW; 0C00459C9C866D1F CRC64;
MGAMMVMMGL LLIIVSLCSA LLRWNQMRYT KNGLPPGTMG WPIFGETTEF LKQGPNFMRN
QRLRYGSFFK SHLLGCPTLI SMDSEVNRYI LKNESKGLVP GYPQSMLDIL GTCNMAAVHG
SSHRLMRGSL LSLISSTMMR DHILPKVDHF MRSYLDQWNE LEVIDIQDKT KHMAFLSSLT
QIAGNLRKPF VEEFKTAFFK LVVGTLSVPI DLPGTNYRCG IQARNNIDRL LRELMQERRD
SGETFTDMLG YLMKKEGNRY PLTDEEIRDQ VVTILYSGYE TVSTTSMMAL KYLHDHPKAL
QELRAEHLAF RERKRQDEPL GLEDVKSMKF TRAVIYETSR LATIVNGVLR KTTRDLEING
YLIPKGWRIY VYTREINYDA NLYEDPLIFN PWRWMKKSLE SQNSCFVFGG GTRLCPGKEL
GIVEISSFLH YFVTRYRWEE IGGDELMVFP RVFAPKGFHL RISPY
