ID   C85CA_DANRE             Reviewed;         391 AA.
AC   Q0P485;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Coiled-coil domain-containing protein 85C-A;
GN   Name=ccdc85ca; ORFNames=zgc:153295;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in cell-cell adhesion and epithelium
CC       development through its interaction with proteins of the beta-catenin
CC       family (By similarity). May play an important role in cortical
CC       development, especially in the maintenance of radial glia (By
CC       similarity). {ECO:0000250|UniProtKB:A6NKD9,
CC       ECO:0000250|UniProtKB:E9Q6B2}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000250|UniProtKB:E9Q6B2}. Cell junction, adherens junction
CC       {ECO:0000250|UniProtKB:A6NKD9}.
CC   -!- SIMILARITY: Belongs to the CCDC85 family. {ECO:0000305}.
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DR   EMBL; BC122223; AAI22224.1; -; mRNA.
DR   RefSeq; NP_001038849.1; NM_001045384.1.
DR   AlphaFoldDB; Q0P485; -.
DR   SMR; Q0P485; -.
DR   STRING; 7955.ENSDARP00000095769; -.
DR   PaxDb; Q0P485; -.
DR   Ensembl; ENSDART00000104999; ENSDARP00000095769; ENSDARG00000005232.
DR   GeneID; 751667; -.
DR   KEGG; dre:751667; -.
DR   CTD; 751667; -.
DR   ZFIN; ZDB-GENE-060825-198; ccdc85ca.
DR   eggNOG; KOG3819; Eukaryota.
DR   GeneTree; ENSGT00940000159071; -.
DR   HOGENOM; CLU_028762_0_0_1; -.
DR   InParanoid; Q0P485; -.
DR   OMA; CENERMK; -.
DR   OrthoDB; 1393196at2759; -.
DR   PhylomeDB; Q0P485; -.
DR   TreeFam; TF320243; -.
DR   PRO; PR:Q0P485; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000005232; Expressed in retina and 19 other tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019359; CCDC85.
DR   PANTHER; PTHR13546; PTHR13546; 1.
DR   Pfam; PF10226; CCDC85; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Coiled coil; Developmental protein; Reference proteome;
KW   Tight junction.
FT   CHAIN           1..391
FT                   /note="Coiled-coil domain-containing protein 85C-A"
FT                   /id="PRO_0000345411"
FT   REGION          154..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          23..87
FT                   /evidence="ECO:0000255"
FT   COILED          121..146
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        158..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..212
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  44164 MW;  C77DCC5567F5E70D CRC64;
     MAKNITDVSR DDLSKVSDEE LQKCSKEELL RRLRKVDAEK MNLMLEHGNM MKDVNRRLQL
     HLHEIRSLKE VNQKLQEDNQ ELRELCCFLD DDRQKGKKLS REWQRFGRYT ASVMWKEVGV
     FQQKLKELES NQDSVMRENL ELKEIIIMLD DERNGAGSRS SIDSQSSLSN LNGGSATVRD
     VGDGSSTSST GSAGSPDHHH SHIHKPTEGK ITSIRRSMDD LSTNHLLRNI PNGLNDSSSN
     YIRQLETKVR ILEDDNKQLL SQQGSVGDLK TLRKGLSLYH SESQLSSLSQ FQDTLQNGSI
     RIAGGDLAPT VTGYLPAAQK PEAVVHAMKV LEVHENLDRK IPEDYEEDLS EKEKAIVREM
     CNVVWRKLGD AAGTKPSIRQ HLSGNQFKGP L