ID   C85CB_DANRE             Reviewed;         399 AA.
AC   Q6DHL7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Coiled-coil domain-containing protein 85C-B;
GN   Name=ccdc85cb; ORFNames=zgc:92236;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in cell-cell adhesion and epithelium
CC       development through its interaction with proteins of the beta-catenin
CC       family (By similarity). May play an important role in cortical
CC       development, especially in the maintenance of radial glia (By
CC       similarity). {ECO:0000250|UniProtKB:A6NKD9,
CC       ECO:0000250|UniProtKB:E9Q6B2}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000250|UniProtKB:E9Q6B2}. Cell junction, adherens junction
CC       {ECO:0000250|UniProtKB:A6NKD9}.
CC   -!- SIMILARITY: Belongs to the CCDC85 family. {ECO:0000305}.
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DR   EMBL; BC075952; AAH75952.1; -; mRNA.
DR   RefSeq; NP_001002628.1; NM_001002628.1.
DR   AlphaFoldDB; Q6DHL7; -.
DR   SMR; Q6DHL7; -.
DR   STRING; 7955.ENSDARP00000097929; -.
DR   PaxDb; Q6DHL7; -.
DR   Ensembl; ENSDART00000182876; ENSDARP00000153712; ENSDARG00000079555.
DR   GeneID; 436901; -.
DR   KEGG; dre:436901; -.
DR   CTD; 436901; -.
DR   ZFIN; ZDB-GENE-040718-373; ccdc85cb.
DR   eggNOG; KOG3819; Eukaryota.
DR   GeneTree; ENSGT00940000159071; -.
DR   HOGENOM; CLU_028762_0_0_1; -.
DR   InParanoid; Q6DHL7; -.
DR   OMA; PMRRSMD; -.
DR   OrthoDB; 1393196at2759; -.
DR   PhylomeDB; Q6DHL7; -.
DR   TreeFam; TF320243; -.
DR   PRO; PR:Q6DHL7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000079555; Expressed in retina and 24 other tissues.
DR   ExpressionAtlas; Q6DHL7; baseline and differential.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019359; CCDC85.
DR   PANTHER; PTHR13546; PTHR13546; 1.
DR   Pfam; PF10226; CCDC85; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Coiled coil; Developmental protein; Reference proteome;
KW   Tight junction.
FT   CHAIN           1..399
FT                   /note="Coiled-coil domain-containing protein 85C-B"
FT                   /id="PRO_0000345412"
FT   REGION          151..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          52..84
FT                   /evidence="ECO:0000255"
FT   COILED          113..144
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        155..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  45094 MW;  72A0BF69D6BF938E CRC64;
     MAKHCPNDDL SKIPDEELVR WSKEDLIRRL RRVDGEKMSL MLEHSNMMKD VNRSLQVHLH
     EIRNLKEINQ KLQDDNQELR ELCCFLDDDR QKGKKLSREW QRFGKFTASS VWKEVSTYQQ
     KLKELEINQE NVLRENAELK DIILMLDEDR NGAGSRSSID SQSSLSNLNG GSGTVRDVGD
     GSSTSSGGSA GSPDHHHNHI HKTVEAKIGT VRRSMDDLSA PHHHRSIPAG LNDASSNYIR
     QLETKVRILE DNNNKLLSQP CSRYSLSKLS MKYNPGDLRA LRKGMTLYHS ESQLSSLPQR
     QEALLNGTGR LQTSESSPST GFISSAQKPE AVVHAMKVLE VHDNLEKQLP EESEEDLSEK
     EKAIVREMCN VVWRKLGDAT GTKPSLRQQL SGNQFKAPL