C8D11_ARATH
ID C8D11_ARATH Reviewed; 509 AA.
AC Q9LHA1;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Cytochrome P450 81D11;
DE EC=1.14.-.-;
GN Name=CYP81D11; OrderedLocusNames=At3g28740; ORFNames=T19N8.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, AND INDUCTION BY CIS-JASMONE.
RX PubMed=18356298; DOI=10.1073/pnas.0710305105;
RA Bruce T.J., Matthes M.C., Chamberlain K., Woodcock C.M., Mohib A.,
RA Webster B., Smart L.E., Birkett M.A., Pickett J.A., Napier J.A.;
RT "cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of
RT multitrophic interactions with aphids and their parasitoids.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:4553-4558(2008).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=21422824; DOI=10.4161/psb.6.4.14915;
RA Matthes M., Bruce T., Chamberlain K., Pickett J., Napier J.;
RT "Emerging roles in plant defense for cis-jasmone-induced cytochrome P450
RT CYP81D11.";
RL Plant Signal. Behav. 6:563-565(2011).
RN [6]
RP INDUCTION BY JASMONATE.
RX PubMed=22452854; DOI=10.1104/pp.112.194274;
RA Koster J., Thurow C., Kruse K., Meier A., Iven T., Feussner I., Gatz C.;
RT "Xenobiotic- and jasmonic acid-inducible signal transduction pathways have
RT become interdependent at the Arabidopsis CYP81D11 promoter.";
RL Plant Physiol. 159:391-402(2012).
RN [7]
RP INDUCTION.
RX PubMed=23349138; DOI=10.1093/jxb/ers389;
RA Stotz H.U., Mueller S., Zoeller M., Mueller M.J., Berger S.;
RT "TGA transcription factors and jasmonate-independent COI1 signalling
RT regulate specific plant responses to reactive oxylipins.";
RL J. Exp. Bot. 64:963-975(2013).
CC -!- FUNCTION: May play a role in cis-jasmone-activated defense response to
CC aphids. {ECO:0000269|PubMed:18356298, ECO:0000269|PubMed:21422824}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in leaf hydathodes.
CC {ECO:0000269|PubMed:21422824}.
CC -!- INDUCTION: By the diamond-back moth Plutella xylostella, the generalist
CC herbivore Spodoptora littoralis, infection with P.syringae, jasmonate,
CC cis-jasmone, phytoprostane A1 and 12-oxo phytodienoic acid (OPDA).
CC {ECO:0000269|PubMed:18356298, ECO:0000269|PubMed:21422824,
CC ECO:0000269|PubMed:22452854, ECO:0000269|PubMed:23349138}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AP002057; BAB03171.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77485.1; -; Genomic_DNA.
DR EMBL; AY050849; AAK92784.1; -; mRNA.
DR EMBL; AY113869; AAM44917.1; -; mRNA.
DR RefSeq; NP_189516.1; NM_113795.2.
DR AlphaFoldDB; Q9LHA1; -.
DR SMR; Q9LHA1; -.
DR STRING; 3702.AT3G28740.1; -.
DR PaxDb; Q9LHA1; -.
DR PRIDE; Q9LHA1; -.
DR ProteomicsDB; 239208; -.
DR EnsemblPlants; AT3G28740.1; AT3G28740.1; AT3G28740.
DR GeneID; 822506; -.
DR Gramene; AT3G28740.1; AT3G28740.1; AT3G28740.
DR KEGG; ath:AT3G28740; -.
DR Araport; AT3G28740; -.
DR TAIR; locus:2098418; AT3G28740.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_4_0_1; -.
DR OMA; FDGKNHE; -.
DR OrthoDB; 702827at2759; -.
DR PhylomeDB; Q9LHA1; -.
DR BioCyc; ARA:AT3G28740-MON; -.
DR PRO; PR:Q9LHA1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LHA1; baseline and differential.
DR Genevisible; Q9LHA1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR GO; GO:0002213; P:defense response to insect; IMP:TAIR.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..509
FT /note="Cytochrome P450 81D11"
FT /id="PRO_0000425849"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 442
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 509 AA; 57692 MW; E6D4A9BB34A06AC8 CRC64;
MSSTKTIMET IYLILSLFFF FIFLSLKLLF GPRPRKLNLP PSPSRPFPII GHLHLLKLPL
HRRFLSLSES LNNAKIFSLS LGSRLVFVVS SHAVAEECFT KNDVVLANRP EFLVGKHIGY
NSTTMVGAAY GDSWRNLRRI GTIEIFSSLR LNSFVSIRQD EIRRLIICLA KNSQHGFVKV
EMKPLFMCLT INNIIRMVAG KRFYGDGTEN DNEAKHVRQL IAEVVVSGGA GNAADYFPIL
RYVTNYEKHV KKLAGRVDEF LQSLVNEKRV EKVKGNTMID HLLSLQETQP DYYTDVIIKG
IILVMILAGT DTSAGTLEWA MSNLLNHPEV LRKAKTEIDD QIGVDRLVEE QDIVKLPYLQ
HIVSETLRLY PVAPMLLPHL ASEDCIVDGY DVPRGTIILV NAWAIHRDPK LWEEPEKFKP
ERFEKKGEDK KLMPFGIGRR SCPGSGLAQR LVTLALGSLV QCFEWERVEE KYLDMRESEK
GTTMRKATSL QAMCKARPIV HKVLDASCP
