UBL3_MOUSE
ID UBL3_MOUSE Reviewed; 117 AA.
AC Q9Z2M6; A4FTW0; Q3UKM1;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Ubiquitin-like protein 3;
DE AltName: Full=Membrane-anchored ubiquitin-fold protein;
DE Short=MUB;
DE Short=MmMUB;
DE AltName: Full=Protein HCG-1;
DE Flags: Precursor;
GN Name=Ubl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10375635; DOI=10.1016/s0378-1119(99)00138-9;
RA Chadwick B.P., Kidd T., Sgouros J., Ish-Horowicz D., Frischauf A.-M.;
RT "Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene.";
RL Gene 233:189-195(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION, NOMENCLATURE, PALMITOYLATION AT CYS-113, AND ISOPRENYLATION
RP AT CYS-114 IN VITRO.
RX PubMed=16831869; DOI=10.1074/jbc.m602283200;
RA Downes B.P., Saracco S.A., Lee S.S., Crowell D.N., Vierstra R.D.;
RT "MUBS: a family of ubiquitin-fold proteins that are plasma membrane-
RT anchored by prenylation.";
RL J. Biol. Chem. 281:27145-27157(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP STRUCTURE BY NMR OF 1-103.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of mouse ubiquitin-like 3 protein.";
RL Submitted (NOV-2004) to the PDB data bank.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}.
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DR EMBL; AF044222; AAD02324.1; -; mRNA.
DR EMBL; AK145952; BAE26780.1; -; mRNA.
DR EMBL; BC024507; AAH24507.1; -; mRNA.
DR EMBL; BC025595; AAH25595.1; -; mRNA.
DR EMBL; BC043729; AAH43729.1; -; mRNA.
DR CCDS; CCDS39403.1; -.
DR RefSeq; NP_036038.1; NM_011908.2.
DR RefSeq; XP_006504895.1; XM_006504832.3.
DR PDB; 1WGH; NMR; -; A=1-103.
DR PDBsum; 1WGH; -.
DR AlphaFoldDB; Q9Z2M6; -.
DR BMRB; Q9Z2M6; -.
DR SMR; Q9Z2M6; -.
DR STRING; 10090.ENSMUSP00000078303; -.
DR iPTMnet; Q9Z2M6; -.
DR PhosphoSitePlus; Q9Z2M6; -.
DR SwissPalm; Q9Z2M6; -.
DR EPD; Q9Z2M6; -.
DR MaxQB; Q9Z2M6; -.
DR PaxDb; Q9Z2M6; -.
DR PRIDE; Q9Z2M6; -.
DR ProteomicsDB; 298451; -.
DR Antibodypedia; 22737; 166 antibodies from 25 providers.
DR Ensembl; ENSMUST00000079324; ENSMUSP00000078303; ENSMUSG00000001687.
DR Ensembl; ENSMUST00000164904; ENSMUSP00000131049; ENSMUSG00000001687.
DR Ensembl; ENSMUST00000201595; ENSMUSP00000144073; ENSMUSG00000001687.
DR GeneID; 24109; -.
DR KEGG; mmu:24109; -.
DR UCSC; uc009aou.1; mouse.
DR CTD; 5412; -.
DR MGI; MGI:1344373; Ubl3.
DR VEuPathDB; HostDB:ENSMUSG00000001687; -.
DR eggNOG; ENOG502RYGN; Eukaryota.
DR GeneTree; ENSGT00390000004952; -.
DR HOGENOM; CLU_151471_0_0_1; -.
DR InParanoid; Q9Z2M6; -.
DR OMA; EWESDRV; -.
DR OrthoDB; 1555986at2759; -.
DR PhylomeDB; Q9Z2M6; -.
DR TreeFam; TF314489; -.
DR BioGRID-ORCS; 24109; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Ubl3; mouse.
DR EvolutionaryTrace; Q9Z2M6; -.
DR PRO; PR:Q9Z2M6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9Z2M6; protein.
DR Bgee; ENSMUSG00000001687; Expressed in extensor digitorum longus and 262 other tissues.
DR Genevisible; Q9Z2M6; MM.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR017000; MUB.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR040015; UBL3-like.
DR InterPro; IPR039540; UBL3-like_ubiquitin_dom.
DR PANTHER; PTHR13169; PTHR13169; 1.
DR Pfam; PF13881; Rad60-SLD_2; 1.
DR PIRSF; PIRSF032572; MUB; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Lipoprotein; Membrane; Methylation; Palmitate;
KW Prenylation; Reference proteome.
FT CHAIN 1..114
FT /note="Ubiquitin-like protein 3"
FT /id="PRO_0000114863"
FT PROPEP 115..117
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000248184"
FT DOMAIN 10..88
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT MOD_RES 114
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000305"
FT LIPID 113
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000305|PubMed:16831869"
FT LIPID 114
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000305|PubMed:16831869"
FT STRAND 7..15
FT /evidence="ECO:0007829|PDB:1WGH"
FT STRAND 17..19
FT /evidence="ECO:0007829|PDB:1WGH"
FT STRAND 21..26
FT /evidence="ECO:0007829|PDB:1WGH"
FT HELIX 32..41
FT /evidence="ECO:0007829|PDB:1WGH"
FT STRAND 42..44
FT /evidence="ECO:0007829|PDB:1WGH"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:1WGH"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:1WGH"
FT STRAND 65..67
FT /evidence="ECO:0007829|PDB:1WGH"
FT TURN 73..77
FT /evidence="ECO:0007829|PDB:1WGH"
FT STRAND 83..90
FT /evidence="ECO:0007829|PDB:1WGH"
FT STRAND 95..97
FT /evidence="ECO:0007829|PDB:1WGH"
SQ SEQUENCE 117 AA; 13180 MW; 2EB3A5102AD06F2D CRC64;
MSSHVPADMI NLRLILVSGK TKEFLFSPND SASDIAKHVY DNWPMDWEEE QVSSPNILRL
IYQGRFLHGN VTLGALKLPF GKTTVMHLVA RETLPEPNSQ GQRNREKTGE SNCCVIL
