ID   UBL4A_ESOLU             Reviewed;         154 AA.
AC   C1BXU5;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Ubiquitin-like protein 4A;
GN   Name=ubl4a;
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RA   Leong J., Jantzen S., Cooper G., Davidson W.S., Koop B.F.;
RT   "Esox lucius ESTs and full-length cDNAs.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC       bag6/bat3 complex, maintains misfolded and hydrophobic patches-
CC       containing proteins in a soluble state and participates in their proper
CC       delivery to the endoplasmic reticulum or alternatively can promote
CC       their sorting to the proteasome where they undergo degradation. The
CC       bag6/bat3 complex is involved in the post-translational delivery of
CC       tail-anchored/type II transmembrane proteins to the endoplasmic
CC       reticulum membrane. Similarly, the bag6/bat3 complex also functions as
CC       a sorting platform for proteins of the secretory pathway that are
CC       mislocalized to the cytosol either delivering them to the proteasome
CC       for degradation or to the endoplasmic reticulum. The bag6/bat3 complex
CC       also plays a role in the endoplasmic reticulum-associated degradation
CC       (ERAD), a quality control mechanism that eliminates unwanted proteins
CC       of the endoplasmic reticulum through their retrotranslocation to the
CC       cytosol and their targeting to the proteasome. It maintains these
CC       retrotranslocated proteins in an unfolded yet soluble state condition
CC       in the cytosol to ensure their proper delivery to the proteasome.
CC       {ECO:0000250|UniProtKB:P11441}.
CC   -!- SUBUNIT: Component of the bag6/bat3 complex.
CC       {ECO:0000250|UniProtKB:P11441}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P11441}. Nucleus {ECO:0000250|UniProtKB:P11441}.
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DR   EMBL; BT079424; ACO13848.1; -; mRNA.
DR   RefSeq; NP_001291952.1; NM_001305023.1.
DR   AlphaFoldDB; C1BXU5; -.
DR   SMR; C1BXU5; -.
DR   STRING; 8010.XP_010874307.1; -.
DR   Ensembl; ENSELUT00000028036; ENSELUP00000018221; ENSELUG00000001164.
DR   GeneID; 105014038; -.
DR   KEGG; els:105014038; -.
DR   CTD; 8266; -.
DR   GeneTree; ENSGT00730000111022; -.
DR   OMA; SMDTSYM; -.
DR   OrthoDB; 1586605at2759; -.
DR   Proteomes; UP000265140; LG13.
DR   Bgee; ENSELUG00000001164; Expressed in muscle tissue and 14 other tissues.
DR   GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   CDD; cd01807; Ubl_UBL4A_like; 1.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   InterPro; IPR041421; Ubl4_C_TUGS.
DR   InterPro; IPR044724; Ubl_UBL4A-like.
DR   Pfam; PF17840; Tugs; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Transport.
FT   CHAIN           1..154
FT                   /note="Ubiquitin-like protein 4A"
FT                   /id="PRO_0000403743"
FT   DOMAIN          1..76
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
SQ   SEQUENCE   154 AA;  17014 MW;  590EEA84CCBF5489 CRC64;
     MILTVKPLQG KECNVQVTED EKVSTVKELV SERLNIPPNQ QRLLYKGKAL ADEHRLSDYS
     IGPEAKLNLV VRPAGERSGV TGMASSNSAV GGVWQTLSTV LAKHFSPADA AKVQEQLIKD
     YERSLRQLSL DDIERLAVRL LHPDSEGMDT SYLD