ID   UBL4A_XENTR             Reviewed;         148 AA.
AC   A4QND0;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Ubiquitin-like protein 4A;
GN   Name=ubl4a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC       bag6/bat3 complex, maintains misfolded and hydrophobic patches-
CC       containing proteins in a soluble state and participates in their proper
CC       delivery to the endoplasmic reticulum or alternatively can promote
CC       their sorting to the proteasome where they undergo degradation. The
CC       bag6/bat3 complex is involved in the post-translational delivery of
CC       tail-anchored/type II transmembrane proteins to the endoplasmic
CC       reticulum membrane. Similarly, the bag6/bat3 complex also functions as
CC       a sorting platform for proteins of the secretory pathway that are
CC       mislocalized to the cytosol either delivering them to the proteasome
CC       for degradation or to the endoplasmic reticulum. The bag6/bat3 complex
CC       also plays a role in the endoplasmic reticulum-associated degradation
CC       (ERAD), a quality control mechanism that eliminates unwanted proteins
CC       of the endoplasmic reticulum through their retrotranslocation to the
CC       cytosol and their targeting to the proteasome. It maintains these
CC       retrotranslocated proteins in an unfolded yet soluble state condition
CC       in the cytosol to ensure their proper delivery to the proteasome.
CC       {ECO:0000250|UniProtKB:P11441}.
CC   -!- SUBUNIT: Component of the bag6/bat3 complex.
CC       {ECO:0000250|UniProtKB:P11441}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P11441}. Nucleus {ECO:0000250|UniProtKB:P11441}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC135438; AAI35439.1; -; mRNA.
DR   RefSeq; NP_001096510.1; NM_001103040.1.
DR   AlphaFoldDB; A4QND0; -.
DR   SMR; A4QND0; -.
DR   STRING; 8364.ENSXETP00000015581; -.
DR   PaxDb; A4QND0; -.
DR   GeneID; 100125140; -.
DR   KEGG; xtr:100125140; -.
DR   CTD; 8266; -.
DR   Xenbase; XB-GENE-6455973; ubl4a.
DR   eggNOG; KOG0001; Eukaryota.
DR   HOGENOM; CLU_119809_0_0_1; -.
DR   InParanoid; A4QND0; -.
DR   OMA; SMDTSYM; -.
DR   OrthoDB; 1586605at2759; -.
DR   PhylomeDB; A4QND0; -.
DR   TreeFam; TF354228; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR   GO; GO:0006620; P:post-translational protein targeting to endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   CDD; cd01807; Ubl_UBL4A_like; 1.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   InterPro; IPR041421; Ubl4_C_TUGS.
DR   InterPro; IPR044724; Ubl_UBL4A-like.
DR   Pfam; PF17840; Tugs; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Transport.
FT   CHAIN           1..148
FT                   /note="Ubiquitin-like protein 4A"
FT                   /id="PRO_0000403749"
FT   DOMAIN          1..76
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
SQ   SEQUENCE   148 AA;  16552 MW;  18179EFB189DDE06 CRC64;
     MQLTVKALKG KEANIQVSEG DTVLAVKRLV EEKLKVPVSQ QRLLFRGKAL ADEHCLAHYS
     IGPGSRLNLM VKEQVAPEGH SGGNTAWKSL SVILRKHFSP TDAERVLEYV QKDYERSLSL
     LSLDDIERLA TRILHPQYSE ATDLGFLD