UBL4B_HUMAN
ID UBL4B_HUMAN Reviewed; 174 AA.
AC Q8N7F7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Ubiquitin-like protein 4B;
GN Name=UBL4B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N7F7; P46379-2: BAG6; NbExp=3; IntAct=EBI-10267507, EBI-10988864;
CC Q8N7F7; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10267507, EBI-5916454;
CC Q8N7F7; Q9UBH0: IL36RN; NbExp=3; IntAct=EBI-10267507, EBI-465156;
CC Q8N7F7; P50222: MEOX2; NbExp=3; IntAct=EBI-10267507, EBI-748397;
CC Q8N7F7; Q9BUZ4: TRAF4; NbExp=7; IntAct=EBI-10267507, EBI-3650647;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: May have arisen from retrotransposition of the X-linked
CC UBL4A gene during mammalian evolution.
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DR EMBL; AK098556; BAC05331.1; -; mRNA.
DR EMBL; BC058929; AAH58929.1; -; mRNA.
DR CCDS; CCDS820.1; -.
DR RefSeq; NP_981957.1; NM_203412.1.
DR AlphaFoldDB; Q8N7F7; -.
DR SMR; Q8N7F7; -.
DR BioGRID; 127890; 14.
DR IntAct; Q8N7F7; 7.
DR STRING; 9606.ENSP00000334044; -.
DR BioMuta; UBL4B; -.
DR DMDM; 74729219; -.
DR MassIVE; Q8N7F7; -.
DR MaxQB; Q8N7F7; -.
DR PaxDb; Q8N7F7; -.
DR PeptideAtlas; Q8N7F7; -.
DR PRIDE; Q8N7F7; -.
DR Antibodypedia; 33782; 62 antibodies from 17 providers.
DR DNASU; 164153; -.
DR Ensembl; ENST00000334179.5; ENSP00000334044.3; ENSG00000186150.5.
DR GeneID; 164153; -.
DR KEGG; hsa:164153; -.
DR MANE-Select; ENST00000334179.5; ENSP00000334044.3; NM_203412.2; NP_981957.1.
DR UCSC; uc001dzc.4; human.
DR CTD; 164153; -.
DR DisGeNET; 164153; -.
DR GeneCards; UBL4B; -.
DR HGNC; HGNC:32309; UBL4B.
DR HPA; ENSG00000186150; Tissue enriched (testis).
DR MIM; 611127; gene.
DR neXtProt; NX_Q8N7F7; -.
DR OpenTargets; ENSG00000186150; -.
DR PharmGKB; PA142670661; -.
DR VEuPathDB; HostDB:ENSG00000186150; -.
DR eggNOG; KOG0001; Eukaryota.
DR GeneTree; ENSGT00940000163477; -.
DR HOGENOM; CLU_119809_0_0_1; -.
DR InParanoid; Q8N7F7; -.
DR OMA; ASINVIM; -.
DR OrthoDB; 1586605at2759; -.
DR PhylomeDB; Q8N7F7; -.
DR TreeFam; TF354228; -.
DR PathwayCommons; Q8N7F7; -.
DR SignaLink; Q8N7F7; -.
DR BioGRID-ORCS; 164153; 15 hits in 1075 CRISPR screens.
DR ChiTaRS; UBL4B; human.
DR GenomeRNAi; 164153; -.
DR Pharos; Q8N7F7; Tdark.
DR PRO; PR:Q8N7F7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N7F7; protein.
DR Bgee; ENSG00000186150; Expressed in left testis and 87 other tissues.
DR Genevisible; Q8N7F7; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; HMP:ParkinsonsUK-UCL.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR041421; Ubl4_C_TUGS.
DR InterPro; IPR043317; UBL4B.
DR PANTHER; PTHR47905; PTHR47905; 1.
DR Pfam; PF17840; Tugs; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..174
FT /note="Ubiquitin-like protein 4B"
FT /id="PRO_0000263701"
FT DOMAIN 1..76
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 141..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 174 AA; 19909 MW; BC49D31A0357C1E5 CRC64;
MFLTVKLLLG QRCSLKVSGQ ESVATLKRLV SRRLKVPEEQ QHLLFRGQLL EDDKHLSDYC
IGPNASINVI MQPLEKMALK EAHQPQTQPL WHQLGLVLAK HFEPQDAKAV LQLLRQEHEE
RLQKISLEHL EQLAQYLLAE EPHVEPAGER ELEAKARPQS SCDMEEKEEA AADQ
