ID   UBL4B_MOUSE             Reviewed;         188 AA.
AC   Q9CQ84; Q5RL34;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Ubiquitin-like protein 4B;
GN   Name=Ubl4b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=16872915; DOI=10.1016/j.modgep.2006.06.002;
RA   Yang F., Skaletsky H., Wang P.J.;
RT   "Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic
RT   germ cells in mammals.";
RL   Gene Expr. Patterns 7:131-136(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16872915}.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in post-meiotic male germ
CC       cells of the testis. Abundantly expressed in stage 14-16 spermatids.
CC       {ECO:0000269|PubMed:16872915}.
CC   -!- MISCELLANEOUS: May have arisen from retrotransposition of the X-linked
CC       Ubl4a gene during mammalian evolution.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH48443.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK006408; BAB24573.1; -; mRNA.
DR   EMBL; AK015868; BAB30008.1; -; mRNA.
DR   EMBL; AK016746; BAB30407.1; -; mRNA.
DR   EMBL; BC048443; AAH48443.1; ALT_FRAME; mRNA.
DR   EMBL; BC061071; AAH61071.1; -; mRNA.
DR   CCDS; CCDS38592.1; -.
DR   RefSeq; NP_080537.1; NM_026261.2.
DR   AlphaFoldDB; Q9CQ84; -.
DR   SMR; Q9CQ84; -.
DR   IntAct; Q9CQ84; 1.
DR   STRING; 10090.ENSMUSP00000100577; -.
DR   PaxDb; Q9CQ84; -.
DR   PRIDE; Q9CQ84; -.
DR   ProteomicsDB; 298452; -.
DR   Antibodypedia; 33782; 62 antibodies from 17 providers.
DR   DNASU; 67591; -.
DR   Ensembl; ENSMUST00000052853; ENSMUSP00000100577; ENSMUSG00000055891.
DR   GeneID; 67591; -.
DR   KEGG; mmu:67591; -.
DR   UCSC; uc008qxe.1; mouse.
DR   CTD; 164153; -.
DR   MGI; MGI:1914841; Ubl4b.
DR   VEuPathDB; HostDB:ENSMUSG00000055891; -.
DR   eggNOG; KOG0001; Eukaryota.
DR   GeneTree; ENSGT00940000163477; -.
DR   HOGENOM; CLU_119809_0_0_1; -.
DR   InParanoid; Q9CQ84; -.
DR   OMA; ASINVIM; -.
DR   OrthoDB; 1586605at2759; -.
DR   PhylomeDB; Q9CQ84; -.
DR   TreeFam; TF354228; -.
DR   BioGRID-ORCS; 67591; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Ubl4b; mouse.
DR   PRO; PR:Q9CQ84; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q9CQ84; protein.
DR   Bgee; ENSMUSG00000055891; Expressed in seminiferous tubule of testis and 20 other tissues.
DR   Genevisible; Q9CQ84; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   InterPro; IPR041421; Ubl4_C_TUGS.
DR   InterPro; IPR043317; UBL4B.
DR   PANTHER; PTHR47905; PTHR47905; 1.
DR   Pfam; PF17840; Tugs; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..188
FT                   /note="Ubiquitin-like protein 4B"
FT                   /id="PRO_0000263702"
FT   DOMAIN          1..76
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          146..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   188 AA;  20518 MW;  B4DD3F68F3644C67 CRC64;
     MFLTVKLLLG RRCSLKVSGK ESVATLKKLV SQHLQVPEEQ QHLLFRGQLL ADDKYLSDYS
     IGPNASINVI MRPPEDAALD KTHQTQPLWL QLGQVLDKHF GAKDAKTVLG FLRQEHEERL
     QRLSLEALEQ LVGQLLAQQQ LDELAEEKEA PAVASELEQN NGGGGGGGGT GGEGGGKKEE
     EEGEEADQ