UBL5_CAEEL
ID UBL5_CAEEL Reviewed; 73 AA.
AC P91302;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Ubiquitin-like protein 5;
GN Name=ubl-5; ORFNames=F46F11.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, INTERACTION WITH DVE-1, AND DISRUPTION PHENOTYPE.
RX PubMed=17925224; DOI=10.1016/j.devcel.2007.07.016;
RA Haynes C.M., Petrova K., Benedetti C., Yang Y., Ron D.;
RT "ClpP mediates activation of a mitochondrial unfolded protein response in
RT C. elegans.";
RL Dev. Cell 13:467-480(2007).
CC -!- FUNCTION: Involved in the mitochondrial unfolded protein response
CC (mtUPR). {ECO:0000269|PubMed:17925224}.
CC -!- SUBUNIT: Interacts with dve-1; the interaction occurs in a
CC mitochondrial stress-dependent manner. {ECO:0000269|PubMed:17925224}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown inhibits expression of
CC hsp-60 when adults are exposed to conditions causing mitochondrial
CC unfolded protein stress. {ECO:0000269|PubMed:17925224}.
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DR EMBL; FO081396; CCD71326.1; -; Genomic_DNA.
DR PIR; T25763; T25763.
DR RefSeq; NP_491640.1; NM_059239.3.
DR AlphaFoldDB; P91302; -.
DR SMR; P91302; -.
DR BioGRID; 50630; 5.
DR IntAct; P91302; 2.
DR STRING; 6239.F46F11.4; -.
DR EPD; P91302; -.
DR PaxDb; P91302; -.
DR PeptideAtlas; P91302; -.
DR EnsemblMetazoa; F46F11.4.1; F46F11.4.1; WBGene00006726.
DR GeneID; 185872; -.
DR KEGG; cel:CELE_F46F11.4; -.
DR UCSC; F46F11.4; c. elegans.
DR CTD; 185872; -.
DR WormBase; F46F11.4; CE10602; WBGene00006726; ubl-5.
DR eggNOG; KOG3493; Eukaryota.
DR GeneTree; ENSGT00390000001945; -.
DR HOGENOM; CLU_156193_2_0_1; -.
DR InParanoid; P91302; -.
DR OMA; HIKLEDY; -.
DR OrthoDB; 1603476at2759; -.
DR PhylomeDB; P91302; -.
DR PRO; PR:P91302; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00006726; Expressed in embryo and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0005667; C:transcription regulator complex; IPI:WormBase.
DR GO; GO:0031386; F:protein tag; IBA:GO_Central.
DR GO; GO:0034514; P:mitochondrial unfolded protein response; IMP:WormBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IGI:UniProtKB.
DR GO; GO:0036211; P:protein modification process; IBA:GO_Central.
DR InterPro; IPR039732; Hub1/Ubl5.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13042; PTHR13042; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..73
FT /note="Ubiquitin-like protein 5"
FT /id="PRO_0000114871"
FT DOMAIN 1..73
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
SQ SEQUENCE 73 AA; 8738 MW; 61CA839BBA4006A4 CRC64;
MIEITVNDRL GKKVRIKCNP SDTIGDLKKL IAAQTGTRWE KIVLKKWYTI YKDHITLMDY
EIHEGFNFEL YYQ
