UBL5_HUMAN
ID UBL5_HUMAN Reviewed; 73 AA.
AC Q9BZL1; Q2NL89;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Ubiquitin-like protein 5;
GN Name=UBL5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Iris;
RX PubMed=11161819; DOI=10.1006/geno.2000.6439;
RA Friedman J.S., Koop B.F., Raymond V., Walter M.A.;
RT "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly
RT expressed and conserved iris genes.";
RL Genomics 71:252-255(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH CLK1; CLK3 AND CLK4.
RX PubMed=12705895; DOI=10.1016/s0006-291x(03)00549-7;
RA Kantham L., Kerr-Bayles L., Godde N., Quick M., Webb R., Sunderland T.,
RA Bond J., Walder K., Augert G., Collier G.;
RT "Beacon interacts with cdc2/cdc28-like kinases.";
RL Biochem. Biophys. Res. Commun. 304:125-129(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [8]
RP STRUCTURE BY NMR, AND INTERACTION WITH CLK4.
RX PubMed=12824502; DOI=10.1110/ps.0382803;
RA McNally T., Huang Q., Janis R.S., Liu Z., Olejniczak E.T., Reilly R.M.;
RT "Structural analysis of UBL5, a novel ubiquitin-like modifier.";
RL Protein Sci. 12:1562-1566(2003).
CC -!- SUBUNIT: Interacts with CLK1, CLK3 and CLK4.
CC {ECO:0000269|PubMed:12705895, ECO:0000269|PubMed:12824502}.
CC -!- INTERACTION:
CC Q9BZL1; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-607755, EBI-10181188;
CC Q9BZL1; Q9NQY0: BIN3; NbExp=3; IntAct=EBI-607755, EBI-2653038;
CC Q9BZL1; Q9BXJ1-2: C1QTNF1; NbExp=3; IntAct=EBI-607755, EBI-11536642;
CC Q9BZL1; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-607755, EBI-10181422;
CC Q9BZL1; Q9BUN5-3: CCDC28B; NbExp=3; IntAct=EBI-607755, EBI-12920646;
CC Q9BZL1; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-607755, EBI-12261896;
CC Q9BZL1; P78358: CTAG1B; NbExp=3; IntAct=EBI-607755, EBI-1188472;
CC Q9BZL1; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-607755, EBI-742802;
CC Q9BZL1; Q5JQS6: GCSAML; NbExp=3; IntAct=EBI-607755, EBI-17857617;
CC Q9BZL1; Q9UBX0: HESX1; NbExp=3; IntAct=EBI-607755, EBI-8470369;
CC Q9BZL1; Q8IV36: HID1; NbExp=3; IntAct=EBI-607755, EBI-743438;
CC Q9BZL1; Q9UGU5: HMGXB4; NbExp=3; IntAct=EBI-607755, EBI-7261162;
CC Q9BZL1; P49639: HOXA1; NbExp=3; IntAct=EBI-607755, EBI-740785;
CC Q9BZL1; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-607755, EBI-10171774;
CC Q9BZL1; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-607755, EBI-10241252;
CC Q9BZL1; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-607755, EBI-726510;
CC Q9BZL1; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-607755, EBI-12516603;
CC Q9BZL1; P23511-2: NFYA; NbExp=3; IntAct=EBI-607755, EBI-11061759;
CC Q9BZL1; O00746: NME4; NbExp=3; IntAct=EBI-607755, EBI-744871;
CC Q9BZL1; Q9NQ35: NRIP3; NbExp=3; IntAct=EBI-607755, EBI-10311735;
CC Q9BZL1; Q3KNR5: PAX4; NbExp=3; IntAct=EBI-607755, EBI-10240813;
CC Q9BZL1; Q96KR7: PHACTR3; NbExp=3; IntAct=EBI-607755, EBI-717068;
CC Q9BZL1; Q96BK5: PINX1; NbExp=3; IntAct=EBI-607755, EBI-721782;
CC Q9BZL1; Q9NR22: PRMT8; NbExp=3; IntAct=EBI-607755, EBI-745545;
CC Q9BZL1; Q9UL46: PSME2; NbExp=3; IntAct=EBI-607755, EBI-741630;
CC Q9BZL1; O43290: SART1; NbExp=4; IntAct=EBI-607755, EBI-607761;
CC Q9BZL1; Q15019-3: SEPTIN2; NbExp=3; IntAct=EBI-607755, EBI-11525407;
CC Q9BZL1; Q9UJW9: SERTAD3; NbExp=4; IntAct=EBI-607755, EBI-748621;
CC Q9BZL1; Q15637-4: SF1; NbExp=3; IntAct=EBI-607755, EBI-12223157;
CC Q9BZL1; P49901: SMCP; NbExp=3; IntAct=EBI-607755, EBI-750494;
CC Q9BZL1; Q9NS25: SPANXB1; NbExp=3; IntAct=EBI-607755, EBI-17197485;
CC Q9BZL1; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-607755, EBI-11995806;
CC Q9BZL1; Q5T0J7-2: TEX35; NbExp=3; IntAct=EBI-607755, EBI-12833746;
CC Q9BZL1; Q8WTV1: THAP3; NbExp=3; IntAct=EBI-607755, EBI-17438286;
CC Q9BZL1; Q08117-2: TLE5; NbExp=3; IntAct=EBI-607755, EBI-11741437;
CC Q9BZL1; Q9HCM9-2: TRIM39; NbExp=3; IntAct=EBI-607755, EBI-11523450;
CC Q9BZL1; Q9BRX9: WDR83; NbExp=2; IntAct=EBI-607755, EBI-7705033;
CC Q9BZL1; Q8N8Y5: ZFP41; NbExp=3; IntAct=EBI-607755, EBI-12224489;
CC Q9BZL1; Q15973: ZNF124; NbExp=3; IntAct=EBI-607755, EBI-2555767;
CC Q9BZL1; Q5T7W0: ZNF618; NbExp=3; IntAct=EBI-607755, EBI-6255994;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11161819}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highest level of expression in heart,
CC skeletal muscle, kidney, liver, iris and lymphoblasts.
CC {ECO:0000269|PubMed:11161819}.
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DR EMBL; AF313915; AAK14178.1; -; mRNA.
DR EMBL; BT007355; AAP36019.1; -; mRNA.
DR EMBL; BC007053; AAH07053.1; -; mRNA.
DR EMBL; BC110839; AAI10840.1; -; mRNA.
DR CCDS; CCDS12219.1; -.
DR RefSeq; NP_001041706.1; NM_001048241.2.
DR RefSeq; NP_077268.1; NM_024292.3.
DR PDB; 1P0R; NMR; -; A=1-73.
DR PDB; 4PYU; X-ray; 2.00 A; A/B/G/K/O/S=1-73.
DR PDB; 6AHD; EM; 3.80 A; A0=1-73.
DR PDB; 7AAV; EM; 4.20 A; q=1-73.
DR PDB; 7ABF; EM; 3.90 A; q=1-73.
DR PDB; 7ABG; EM; 7.80 A; q=1-73.
DR PDB; 7ABI; EM; 8.00 A; q=1-73.
DR PDBsum; 1P0R; -.
DR PDBsum; 4PYU; -.
DR PDBsum; 6AHD; -.
DR PDBsum; 7AAV; -.
DR PDBsum; 7ABF; -.
DR PDBsum; 7ABG; -.
DR PDBsum; 7ABI; -.
DR AlphaFoldDB; Q9BZL1; -.
DR BMRB; Q9BZL1; -.
DR SMR; Q9BZL1; -.
DR BioGRID; 121872; 72.
DR IntAct; Q9BZL1; 54.
DR MINT; Q9BZL1; -.
DR STRING; 9606.ENSP00000351492; -.
DR GlyGen; Q9BZL1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BZL1; -.
DR MetOSite; Q9BZL1; -.
DR PhosphoSitePlus; Q9BZL1; -.
DR BioMuta; UBL5; -.
DR DMDM; 52082771; -.
DR EPD; Q9BZL1; -.
DR jPOST; Q9BZL1; -.
DR MassIVE; Q9BZL1; -.
DR MaxQB; Q9BZL1; -.
DR PaxDb; Q9BZL1; -.
DR PeptideAtlas; Q9BZL1; -.
DR PRIDE; Q9BZL1; -.
DR ProteomicsDB; 79866; -.
DR Antibodypedia; 25091; 123 antibodies from 19 providers.
DR DNASU; 59286; -.
DR Ensembl; ENST00000358666.7; ENSP00000351492.2; ENSG00000198258.11.
DR Ensembl; ENST00000586895.6; ENSP00000468656.1; ENSG00000198258.11.
DR Ensembl; ENST00000590068.1; ENSP00000466910.1; ENSG00000198258.11.
DR GeneID; 59286; -.
DR KEGG; hsa:59286; -.
DR MANE-Select; ENST00000586895.6; ENSP00000468656.1; NM_001048241.3; NP_001041706.1.
DR UCSC; uc002mmi.3; human.
DR CTD; 59286; -.
DR DisGeNET; 59286; -.
DR GeneCards; UBL5; -.
DR HGNC; HGNC:13736; UBL5.
DR HPA; ENSG00000198258; Low tissue specificity.
DR MIM; 606849; gene.
DR neXtProt; NX_Q9BZL1; -.
DR OpenTargets; ENSG00000198258; -.
DR PharmGKB; PA37805; -.
DR VEuPathDB; HostDB:ENSG00000198258; -.
DR eggNOG; KOG3493; Eukaryota.
DR GeneTree; ENSGT00390000001945; -.
DR HOGENOM; CLU_156193_2_0_1; -.
DR InParanoid; Q9BZL1; -.
DR OMA; HIKLEDY; -.
DR OrthoDB; 1603476at2759; -.
DR PhylomeDB; Q9BZL1; -.
DR PathwayCommons; Q9BZL1; -.
DR SignaLink; Q9BZL1; -.
DR BioGRID-ORCS; 59286; 814 hits in 1074 CRISPR screens.
DR ChiTaRS; UBL5; human.
DR EvolutionaryTrace; Q9BZL1; -.
DR GeneWiki; UBL5; -.
DR GenomeRNAi; 59286; -.
DR Pharos; Q9BZL1; Tbio.
DR PRO; PR:Q9BZL1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BZL1; protein.
DR Bgee; ENSG00000198258; Expressed in adenohypophysis and 204 other tissues.
DR ExpressionAtlas; Q9BZL1; baseline and differential.
DR Genevisible; Q9BZL1; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031386; F:protein tag; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; HMP:ParkinsonsUK-UCL.
DR GO; GO:0036211; P:protein modification process; IBA:GO_Central.
DR InterPro; IPR039732; Hub1/Ubl5.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13042; PTHR13042; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..73
FT /note="Ubiquitin-like protein 5"
FT /id="PRO_0000114866"
FT DOMAIN 1..73
FT /note="Ubiquitin-like"
FT STRAND 1..7
FT /evidence="ECO:0007829|PDB:4PYU"
FT TURN 9..11
FT /evidence="ECO:0007829|PDB:1P0R"
FT STRAND 13..19
FT /evidence="ECO:0007829|PDB:4PYU"
FT HELIX 24..34
FT /evidence="ECO:0007829|PDB:4PYU"
FT HELIX 39..41
FT /evidence="ECO:0007829|PDB:4PYU"
FT STRAND 42..46
FT /evidence="ECO:0007829|PDB:4PYU"
FT TURN 57..61
FT /evidence="ECO:0007829|PDB:4PYU"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:4PYU"
SQ SEQUENCE 73 AA; 8547 MW; D68BC941536AA39F CRC64;
MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI FKDHVSLGDY
EIHDGMNLEL YYQ
