UBL5_MOUSE
ID UBL5_MOUSE Reviewed; 73 AA.
AC Q9EPV8;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ubiquitin-like protein 5;
GN Name=Ubl5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, Pancreas, Spinal ganglion, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP STRUCTURE BY NMR OF 1-73.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the murine ubiquitin-like 5 protein from RIKEN cDNA
RT 0610031K06.";
RL Submitted (DEC-2003) to the PDB data bank.
CC -!- SUBUNIT: Interacts with CLK1, CLK3 and CLK4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AK002730; BAB22312.1; -; mRNA.
DR EMBL; AK003992; BAB23111.1; -; mRNA.
DR EMBL; AK007726; BAB25215.1; -; mRNA.
DR EMBL; AK009854; BAB26545.1; -; mRNA.
DR EMBL; AK012803; BAB28481.1; -; mRNA.
DR EMBL; AK051149; BAC34537.1; -; mRNA.
DR EMBL; BC028498; AAH28498.1; -; mRNA.
DR CCDS; CCDS52733.1; -.
DR RefSeq; NP_079677.1; NM_025401.3.
DR RefSeq; XP_006510607.1; XM_006510544.2.
DR PDB; 1UH6; NMR; -; A=1-73.
DR PDBsum; 1UH6; -.
DR AlphaFoldDB; Q9EPV8; -.
DR BMRB; Q9EPV8; -.
DR SMR; Q9EPV8; -.
DR STRING; 10090.ENSMUSP00000123971; -.
DR iPTMnet; Q9EPV8; -.
DR PhosphoSitePlus; Q9EPV8; -.
DR EPD; Q9EPV8; -.
DR MaxQB; Q9EPV8; -.
DR PaxDb; Q9EPV8; -.
DR PRIDE; Q9EPV8; -.
DR ProteomicsDB; 297789; -.
DR DNASU; 66177; -.
DR Ensembl; ENSMUST00000129414; ENSMUSP00000123971; ENSMUSG00000084786.
DR Ensembl; ENSMUST00000160124; ENSMUSP00000125364; ENSMUSG00000084786.
DR Ensembl; ENSMUST00000160682; ENSMUSP00000124672; ENSMUSG00000084786.
DR Ensembl; ENSMUST00000162303; ENSMUSP00000124812; ENSMUSG00000084786.
DR GeneID; 66177; -.
DR KEGG; mmu:66177; -.
DR UCSC; uc009ojc.1; mouse.
DR CTD; 59286; -.
DR MGI; MGI:1913427; Ubl5.
DR VEuPathDB; HostDB:ENSMUSG00000084786; -.
DR eggNOG; KOG3493; Eukaryota.
DR GeneTree; ENSGT00390000001945; -.
DR HOGENOM; CLU_156193_2_0_1; -.
DR InParanoid; Q9EPV8; -.
DR OMA; HIKLEDY; -.
DR PhylomeDB; Q9EPV8; -.
DR TreeFam; TF318874; -.
DR BioGRID-ORCS; 66177; 29 hits in 71 CRISPR screens.
DR ChiTaRS; Ubl5; mouse.
DR EvolutionaryTrace; Q9EPV8; -.
DR PRO; PR:Q9EPV8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9EPV8; protein.
DR Bgee; ENSMUSG00000084786; Expressed in embryonic brain and 206 other tissues.
DR ExpressionAtlas; Q9EPV8; baseline and differential.
DR Genevisible; Q9EPV8; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031386; F:protein tag; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IBA:GO_Central.
DR InterPro; IPR039732; Hub1/Ubl5.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13042; PTHR13042; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..73
FT /note="Ubiquitin-like protein 5"
FT /id="PRO_0000114868"
FT DOMAIN 1..73
FT /note="Ubiquitin-like"
FT STRAND 1..7
FT /evidence="ECO:0007829|PDB:1UH6"
FT STRAND 9..12
FT /evidence="ECO:0007829|PDB:1UH6"
FT STRAND 14..19
FT /evidence="ECO:0007829|PDB:1UH6"
FT HELIX 24..35
FT /evidence="ECO:0007829|PDB:1UH6"
FT HELIX 39..41
FT /evidence="ECO:0007829|PDB:1UH6"
FT STRAND 43..46
FT /evidence="ECO:0007829|PDB:1UH6"
FT HELIX 57..60
FT /evidence="ECO:0007829|PDB:1UH6"
FT STRAND 66..71
FT /evidence="ECO:0007829|PDB:1UH6"
SQ SEQUENCE 73 AA; 8547 MW; D68BC941536AA39F CRC64;
MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI FKDHVSLGDY
EIHDGMNLEL YYQ
